Technology Process of Butanoic acid, 2-[(phenylthio)methyl]-, methyl ester
There total 1 articles about Butanoic acid, 2-[(phenylthio)methyl]-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
titanium tetrachloride;
In
dichloromethane;
at -78 ℃;
for 4.5h;
DOI:10.1248/cpb.39.2225
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) trimethylaluminum, NH4Cl / 1.) a) hexane, benzene, 0 deg C, 20 min, b) r.t., 45 min, 2.) reflux, 3 h
2: NaIO4 / methanol / Ambient temperature
3: 75 percent / ZnI2 / acetonitrile / 14 h / 50 °C
4: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
5: ZnI2 / acetonitrile / 1 h / -20 °C
6: 98 percent / titanium tetraisopropoxide / 2 h / 80 °C
7: 85 percent / Bu4NF*3H2O, AcOH / tetrahydrofuran / 0.5 h / 0 °C
With
titanium(IV) isopropylate; sodium periodate; tetrabutyl ammonium fluoride; trimethylaluminum; ammonium chloride; acetic acid; 3-chloro-benzenecarboperoxoic acid;
zinc(II) iodide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1248/cpb.39.2225
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) trimethylaluminum / 1.) a) hexane, benzene, -10 deg C, 20 min, b) r.t., 45 min, 2.) reflux, 2 h
2: 95 percent / NaIO4 / methanol / Ambient temperature
3: 63 percent / 1-(dimethyl-tert-butylsiloxy)-1-methoxyethylene / ZnI2 / acetonitrile / 24 h / Ambient temperature
With
sodium periodate; trimethylaluminum; ketene t-butyldimethylsilyl methyl acetal;
zinc(II) iodide;
In
methanol; acetonitrile;
DOI:10.1248/cpb.39.2225
