2'-Deoxy-2'-methylidene-5-fluorocytidine

Base Information

Chemical Name:2'-Deoxy-2'-methylidene-5-fluorocytidine
CAS No.:129531-96-0
Molecular Formula:C₁₀H₁₂FN₃O₄
Molecular Weight:257.221
Hs Code.:
DSSTox Substance ID:DTXSID00156197
Nikkaji Number:J374.409D
Wikidata:Q83024227
ChEMBL ID:CHEMBL3142569
Mol file:129531-96-0.mol

Synonyms:2'-deoxy-2'-methylidene-5-fluorocytidine;2-DMFC

Suppliers and Price of 2'-Deoxy-2'-methylidene-5-fluorocytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2'-Deoxy-2'-methylidene-5-fluorocytidine

Chemical Property:

Boiling Point:464.7°Cat760mmHg
Flash Point:234.8°C
PSA：111.59000
Density:1.72g/cm³
LogP:-0.88620
XLogP3:-1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:257.08118403
Heavy Atom Count:18
Complexity:462

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=C1C(C(OC1N2C=C(C(=NC2=O)N)F)CO)O
Isomeric SMILES:C=C1[C@@H]([C@H](O[C@H]1N2C=C(C(=NC2=O)N)F)CO)O

Technology Process of 2'-Deoxy-2'-methylidene-5-fluorocytidine

There total 3 articles about 2'-Deoxy-2'-methylidene-5-fluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 129532-07-6
1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-5-fluorocytosine

: 129531-96-0
2'-deoxy-2'-methylidene-5-fluorocytidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00106a049

Reference yield:

: 129532-06-5
1-<2-deoxy-2-methylidene-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-5-fluorouracil

: 129531-96-0
2'-deoxy-2'-methylidene-5-fluorocytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature

2: NH₄OH / dioxane / 4 h / Ambient temperature

3: 78 percent / n-Bu₄F / tetrahydrofuran / 1.5 h / Ambient temperature

With pyridine; ammonium hydroxide; 4-chlorophenylphosphorodichloridate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00112a040

Reference yield:

: 5-Fluoro-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-3-methylene-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one

: 129531-96-0
2'-deoxy-2'-methylidene-5-fluorocytidine

Guidance literature:: Multi-step reaction with 2 steps

1: NH₄OH / dioxane / 4 h / Ambient temperature

2: 78 percent / n-Bu₄F / tetrahydrofuran / 1.5 h / Ambient temperature

With ammonium hydroxide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00112a040