(3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol

Base Information

Chemical Name:(3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol
CAS No.:138490-98-9
Molecular Formula:C10H11F3O3
Molecular Weight:236.191
Hs Code.:
DSSTox Substance ID:DTXSID40568755
Wikidata:Q82455102
Mol file:138490-98-9.mol

Synonyms:138490-98-9;(3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol;[3,4-Dimethoxy-2-(trifluoromethyl)phenyl]methanol;Benzenemethanol, 3,4-dimethoxy-2-(trifluoromethyl)-;DTXSID40568755;QQEVWZMTFIRWPZ-UHFFFAOYSA-N

Suppliers and Price of (3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:236.06602869
Heavy Atom Count:16
Complexity:220

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1)CO)C(F)(F)F)OC

Technology Process of (3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol

There total 4 articles about (3,4-Dimethoxy-2-(trifluoromethyl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 138490-96-7
3,4-dimethoxy-2-(trifluoromethyl)benzaldehyde

: 138490-98-9
3,4-dimethoxy-2-(trifluoromethyl)benzyl alcohol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; at 40 ℃; for 2.5h;
DOI:10.1021/jm00081a007

Reference yield:

: 621-59-0
isovanillin

: 138490-98-9
3,4-dimethoxy-2-(trifluoromethyl)benzyl alcohol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / pyridine, iodine monochloride / dioxane / 144 h / Ambient temperature

2: 85 percent / potassium carbonate / acetone / 6 h / Heating

3: 40 percent / cuprous iodide / various solvent(s) / 4 h / 175 °C

4: 87 percent / sodium borohydride / tetrahydrofuran; H₂O / 2.5 h / 40 °C

With pyridine; sodium tetrahydroborate; copper(l) iodide; Iodine monochloride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; acetone;
DOI:10.1021/jm00081a007

Reference yield:

: 138490-95-6
2-iodo-3,4-dimethoxybenzaldehyde

: 138490-98-9
3,4-dimethoxy-2-(trifluoromethyl)benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / cuprous iodide / various solvent(s) / 4 h / 175 °C

2: 87 percent / sodium borohydride / tetrahydrofuran; H₂O / 2.5 h / 40 °C

With sodium tetrahydroborate; copper(l) iodide; In tetrahydrofuran; water;
DOI:10.1021/jm00081a007