Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 138494-32-3
• Molecular Formula: C48H61ClN7O10P
• Molecular Weight: 962.48

Synonyms:

Chemical Property of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

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Safty Information:

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Useful:

Technology Process of Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 5 articles about Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + N-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-chloro-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide → 3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N2-isobutyrylguanosine (138494-32-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N2-isobutyrylguanosine (138494-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine

2: 83 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

N2-isobutyryl-2'-O-<1-(2-chloroethoxy)ethyl>guanosine (138078-25-8) → 3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N2-isobutyrylguanosine (138494-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine

2: 83 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)96193-9

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

4,4'-dimethoxytrityl chloride

N²-isobutyryl-2'-O-<1-(2-chloroethoxy)ethyl>guanosine

3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine

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