Technology Process of Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-,
(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl ester
There total 2 articles about Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-,
(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-(tert-butoxycarbonylamino)hexanoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Cooling with ice;
5-fluoro-1-(hydroxymethyl) pyrimidine-2,4-(1H,3H)-dione;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 3h;
DOI:10.1016/j.ejmech.2017.11.074
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 20 °C
2: triethylamine / N,N-dimethyl-formamide / 20 °C
With
tetra(n-butyl)ammonium hydrogensulfate; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Cooling with ice
2.2: 3 h / 20 °C
3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C
With
hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2017.11.074
