3-[2,3-o-(1-Methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

Base Information

Chemical Name:3-[2,3-o-(1-Methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine
CAS No.:53458-40-5
Molecular Formula:C₁₂H₁₆N₆O₄
Molecular Weight:308.297
Hs Code.:
NSC Number:163473
DSSTox Substance ID:DTXSID30968144
Mol file:53458-40-5.mol

Synonyms:53458-40-5;NSC163473;3-[2,3-o-(1-methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine;SCHEMBL3320035;DTXSID30968144;UNEASZMGCIBIBZ-UHFFFAOYSA-N;ZINC01635702;NSC-163473;[6-(7-amino-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-methanol

Suppliers and Price of 3-[2,3-o-(1-Methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 3-[2,3-o-(1-Methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

Chemical Property:

Vapor Pressure:1.51E-14mmHg at 25°C
Boiling Point:585.4°Cat760mmHg
Flash Point:307.9°C
Density:1.94g/cm³
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:308.12330301
Heavy Atom Count:22
Complexity:440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(OC2C(OC(C2O1)N3C4=NC=NC(=C4N=N3)N)CO)C

Technology Process of 3-[2,3-o-(1-Methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine

There total 7 articles about 3-[2,3-o-(1-Methylethylidene)pentofuranosyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

: 149355-98-6
5'-O-benzyl-2',3'-O-isopropylidene-8-azaadenosine

: 53458-40-5
8-Aza-2',3'-O-isopropylidene-adenosine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 20h; under 760 Torr;

Reference yield:

: 5975-09-7
2,3-O-isopropylidene-β-D-ribofuranosyl-1-azide

: 53458-40-5
8-Aza-2',3'-O-isopropylidene-adenosine

Guidance literature:: Multi-step reaction with 5 steps

1: 81.5 percent / 50percent aq. NaOH, benzyltriethylammonium bromide / CH₂Cl₂ / 4 h / Ambient temperature

2: 1.) NaOEt / 1.) 50 deg C, 5 h, 2.) reflux, 20 h

3: POCl₃, diethylaniline / 2 h / 95 °C

4: 32percent aq. NH₄OH / ethanol / 1.5 h / 80 °C

5: 57.5 percent / H₂ / 10percent Pd/C / methanol / 20 h / 760 Torr

With ammonium hydroxide; sodium hydroxide; hydrogen; sodium ethanolate; benzyltriethylammonium bromide; N,N-diethylaniline; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; dichloromethane;

Reference yield:

: 149355-96-4
5-O-benzyl-2,3-O-isopropylidene-1-azido-β-D-ribofuranose

: 53458-40-5
8-Aza-2',3'-O-isopropylidene-adenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaOEt / 1.) 50 deg C, 5 h, 2.) reflux, 20 h

2: POCl₃, diethylaniline / 2 h / 95 °C

3: 32percent aq. NH₄OH / ethanol / 1.5 h / 80 °C

4: 57.5 percent / H₂ / 10percent Pd/C / methanol / 20 h / 760 Torr

With ammonium hydroxide; hydrogen; sodium ethanolate; N,N-diethylaniline; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol;