3,5,8-Trihydroxy-3',4',7-trimethoxyflavone

Base Information

Chemical Name:3,5,8-Trihydroxy-3',4',7-trimethoxyflavone
CAS No.:89971-05-1
Molecular Formula:C₁₈H₁₆O₈
Molecular Weight:360.32
Hs Code.:
DSSTox Substance ID:DTXSID80237958
Wikidata:Q83120230
Metabolomics Workbench ID:49186

Synonyms:3,5,8-Trihydroxy-3',4',7-trimethoxyflavone;89971-05-1;4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3,5,8-trihydroxy-7-methoxy-;2-(3,4-Dimethoxyphenyl)-3,5,8-trihydroxy-7-methoxy-4H-1-benzopyran-4-one;DTXSID80237958;CHEBI:175615;2-(3,4-dimethoxyphenyl)-3,5,8-trihydroxy-7-methoxychromen-4-one;2-(3,4-dimethoxyphenyl)-3,5,8-trihydroxy-7-methoxy-4H-chromen-4-one

Suppliers and Price of 3,5,8-Trihydroxy-3',4',7-trimethoxyflavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 3,5,8-Trihydroxy-3',4',7-trimethoxyflavone

Chemical Property:

Vapor Pressure:1.07E-15mmHg at 25°C
Boiling Point:609.3°Cat760mmHg
Flash Point:223.4°C
Density:1.482g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:360.08451746
Heavy Atom Count:26
Complexity:561

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C=C3O)OC)O)O)OC

Technology Process of 3,5,8-Trihydroxy-3',4',7-trimethoxyflavone

There total 6 articles about 3,5,8-Trihydroxy-3',4',7-trimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7380-44-1
5,8-dihydroxy-3,7-dimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone

: 89971-05-1
3,5,8-trihydroxy-3',4',7-trimethoxyflavone

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / Ambient temperature

2: potassium carbonate / acetone

3: 97 percent / 10percent aluminum bromide/acetonitrile

4: N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / Ambient temperature

5: potassium carbonate / methanol / 2 h / Heating

6: hydrochloric acid, acetic acid / 1 h / Ambient temperature

With hydrogenchloride; aluminum tri-bromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; acetonitrile; In methanol; dichloromethane; acetone;
DOI:10.1246/bcsj.66.2668

Reference yield:

: 154048-49-4
2-(3,4-Dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methoxymethoxy-chromen-4-one

: 89971-05-1
3,5,8-trihydroxy-3',4',7-trimethoxyflavone

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone

2: 97 percent / 10percent aluminum bromide/acetonitrile

3: N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / Ambient temperature

4: potassium carbonate / methanol / 2 h / Heating

5: hydrochloric acid, acetic acid / 1 h / Ambient temperature

With hydrogenchloride; aluminum tri-bromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; acetonitrile; In methanol; dichloromethane; acetone;
DOI:10.1246/bcsj.66.2668

Reference yield:

: 154048-53-0
Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3,8-dihydroxy-7-methoxy-4-oxo-4H-chromen-5-yl ester

: 89971-05-1
3,5,8-trihydroxy-3',4',7-trimethoxyflavone

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / Ambient temperature

2: potassium carbonate / methanol / 2 h / Heating

3: hydrochloric acid, acetic acid / 1 h / Ambient temperature

With hydrogenchloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1246/bcsj.66.2668