Aids003925

Base Information

Chemical Name:Aids003925
CAS No.:141706-86-7
Molecular Formula:C₂₃H₄₁N₃O₈SSi₂
Molecular Weight:575.831
Hs Code.:

Synonyms:2,4(1H,3H)-Pyrimidinedione,1-[4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-,S,S-dioxide, [5S-(5a,6a,8a,9b)]-; 1,7-Dioxa-2-thiaspiro[4.4]nonane, 2,4(1H,3H)-pyrimidinedione deriv.

Suppliers and Price of Aids003925

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Aids003925

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：160.58000
Density:1.24g/cm³
LogP:4.93850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Aids003925

There total 2 articles about Aids003925 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 141706-84-5
1-<2',5'-bis-O-(tert-butyldimethylsilyl)-3'-C-cyano-3'-O-mesyl-β-D-xylofuranosyl>uracil

: 141706-86-7
<1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>uracil>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide>

Guidance literature:: With caesium carbonate; In acetonitrile; for 8h; Ambient temperature;
DOI:10.1021/jm00093a002

Reference yield:

: 90813-54-0
2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine

: 141706-86-7
<1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-xylofuranosyl>uracil>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide>

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq. NaHCO₃, 2.) pyridine / 1.) Et₂O, RT, 16 h, 2.) from 8 deg C to 10 deg C, 48 h

2: 80 percent / Cs₂CO₃ / acetonitrile / 8 h / Ambient temperature

With pyridine; sodium hydrogencarbonate; caesium carbonate; In acetonitrile;
DOI:10.1021/jm00093a002