2-(Benzyloxy)-5-chloroaniline

Base Information

• Chemical Name: 2-(Benzyloxy)-5-chloroaniline
• CAS No.: 6373-47-3
• Molecular Formula: C16H14N4O2S
• Molecular Weight: 233.697
• Hs Code.: 2922199090
• Mol file: 6373-47-3.mol

Synonyms:2-(benzyloxy)-5-chloroaniline;6373-47-3;2-(benzyloxy)-5-chlorobenzenamine;5-chloro-2-phenylmethoxyaniline;2-benzyloxy-5-chloroaniline;2-Benzyloxy-5-chloro-aniline;SCHEMBL4882597;2-(benzyloxy)-5-chloro-aniline;2-(Benzyloxy)-5-chloro Aniline;UJZOHHSRILPGAX-UHFFFAOYSA-N;2-(benzyloxy)-5-chlorophenylamine;AKOS000198057;SB80778;NCGC00326291-01;BB 0259274;CS-0270071;EN300-195860;AB01320973-02;AN-329/43341939

Chemical Property of 2-(Benzyloxy)-5-chloroaniline

Chemical Property:

• PSA: 35.25000
• Density: 1.388g/cm³
• LogP: 4.08240
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 233.0607417
• Heavy Atom Count: 16
• Complexity: 206

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzyloxy)-5-chloroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)Cl)N

Technology Process of 2-(Benzyloxy)-5-chloroaniline

There total 7 articles about 2-(Benzyloxy)-5-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(benzyloxy)-4-chloro-2-nitrobenzene (92044-52-5) → 2-(benzyloxy)-5-chloroaniline (6373-47-3)

Guidance literature:

With zinc; In acetic acid; at 20 ℃;

Reference yield: 68.0%

C21H14ClNO3 (1289485-53-5) → 2-(benzyloxy)-5-chloroaniline (6373-47-3)

Guidance literature:

With water; hydrazine; In ethanol; for 2h; Reflux;

DOI:10.1016/j.bmc.2011.01.043

Reference yield:

2-(5-chloro-2-hydroxy-phenyl)-isoindole-1,3-dione (80460-34-0) → 2-(benzyloxy)-5-chloroaniline (6373-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: water; hydrazine / ethanol / 2 h / Reflux

With water; potassium carbonate; hydrazine; In ethanol; acetone;

DOI:10.1016/j.bmc.2011.01.043

upstream raw materials:

1-(benzyloxy)-4-chloro-2-nitrobenzene

C₂₁H₁₄ClNO₃

2-hydroxy-5-chloro-aniline

2-(5-chloro-2-hydroxy-phenyl)-isoindole-1,3-dione

Downstream raw materials:

2-benzyloxy-5-chloroiodobenzene

N-(2-Benzyloxy-5-chloro-phenyl)-N'-(2-methoxy-phenyl)-oxalamide

2-(2-benzyloxy-5-chloro-phenylthiocarbamoyl)-2-cyano-acetamide

6H-2-chloro-dibenzopyran-6-one