3-(9h-Fluoren-9-ylidenemethyl)pyridine

Base Information

• Chemical Name: 3-(9h-Fluoren-9-ylidenemethyl)pyridine
• CAS No.: 3239-00-7
• Molecular Formula: C19H13N
• Molecular Weight: 255.3132
• NSC Number: 83320
• DSSTox Substance ID: DTXSID10292510
• Nikkaji Number: J3.149.280G
• Pharos Ligand ID: LS7ZPPHT7V7L
• ChEMBL ID: CHEMBL194928
• Mol file: 3239-00-7.mol

Synonyms:3-(9h-fluoren-9-ylidenemethyl)pyridine;3239-00-7;3-((9H-Fluoren-9-ylidene)methyl)pyridine;NSC83320;NCIOpen2_004633;BDBM8637;CHEMBL194928;SCHEMBL8276088;(3-Pyridylmethylene)fluorene 32;DTXSID10292510;NSC-83320;PD181388

Chemical Property of 3-(9h-Fluoren-9-ylidenemethyl)pyridine

Chemical Property:

• Vapor Pressure: 1.82E-06mmHg at 25°C
• Boiling Point: 407.1°Cat760mmHg
• Flash Point: 179.7°C
• Density: 1.219g/cm³
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 255.104799419
• Heavy Atom Count: 20
• Complexity: 348

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3C2=CC4=CN=CC=C4

Technology Process of 3-(9h-Fluoren-9-ylidenemethyl)pyridine

There total 5 articles about 3-(9h-Fluoren-9-ylidenemethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-iodobiphenyl (2113-51-1) + 3-(β-bromovinyl)pyridine (628703-07-1,671224-97-8) → 3-((9H-fluoren-9-ylidene)methyl)pyridine (3239-00-7)

Guidance literature:

With palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine; In dimethyl sulfoxide; at 120 ℃; for 24h; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1039/d1ob01547h

Reference yield: 70.0%

3-pyridinecarboxaldehyde (500-22-1) + 9H-fluorene (86-73-7) → 3-((9H-fluoren-9-ylidene)methyl)pyridine (3239-00-7)

Guidance literature:

With potassium hydroxide; In 1,2-dimethoxyethane; for 4h; Reflux;

DOI:10.1021/ic301559s

Reference yield:

9-Fluorenol (1689-64-1) → 3-((9H-fluoren-9-ylidene)methyl)pyridine (3239-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 12 h / Heating

2: K₂CO₃; 18-crown-6 / CH₂Cl₂ / 12 h / Heating

With 18-crown-6 ether; potassium carbonate; In dichloromethane; benzene; 2: Wittig reaction;

DOI:10.1021/jm0492397

upstream raw materials:

3-pyridinecarboxaldehyde

(9H-fluoren-9-yl)triphenylphosphonium bromide

9-Fluorenol

9H-fluorene