2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBONITRILE

Base Information

• Chemical Name: 2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBONITRILE
• CAS No.: 27036-90-4
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• Mol file: 27036-90-4.mol

Synonyms:Nicotinonitrile,1,4,5,6-tetrahydro-2-methyl-6-oxo- (8CI)

Chemical Property of 2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBONITRILE

Chemical Property:

• Vapor Pressure: 5.22E-05mmHg at 25°C
• Melting Point: 222-224°C
• Boiling Point: 347.9°Cat760mmHg
• Flash Point: 164.2°C
• PSA: 52.89000
• Density: 1.15g/cm³
• LogP: 1.02278

Purity/Quality:

97% ^*data from raw suppliers

2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBONITRILE

There total 4 articles about 2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-3-aminocrotononitrile (763-33-7) + acryloyl chloride (814-68-6,25189-84-8) → 6-methyl-1,2,3,4-tetrahydro-2-pyridinone-5-carbonitrile (27036-90-4)

Guidance literature:

In tetrahydrofuran; at 66 ℃;

DOI:10.1021/jo00086a009

Reference yield: 82.0%

2-aminocrotononitrile (870-64-4) + acryloyl chloride (814-68-6,25189-84-8) → 6-methyl-1,2,3,4-tetrahydro-2-pyridinone-5-carbonitrile (27036-90-4)

Guidance literature:

DOI:10.1016/S0040-4039(00)61389-8

Reference yield:

(2R,3R)-2-Dimethylamino-2-methyl-6-methylsulfanyl-2,3,4,5-tetrahydro-pyridine-3-carbonitrile → 6-methyl-1,2,3,4-tetrahydro-2-pyridinone-5-carbonitrile (27036-90-4)

Guidance literature:

With water;

DOI:10.1016/0040-4020(96)00546-7

upstream raw materials:

(E)-3-aminocrotononitrile

acryloyl chloride

2-aminocrotononitrile

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