2H-Isoindole-2-acetamide, N-[(7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-yl)methyl]-1, 3-dihydro-1,3-dioxo-, monohydrochloride

Base Information

• Chemical Name: 2H-Isoindole-2-acetamide, N-[(7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-yl)methyl]-1, 3-dihydro-1,3-dioxo-, monohydrochloride
• CAS No.: 138729-70-1
• Molecular Formula: C26H21ClN4O3.ClH
• Molecular Weight: 509.392

Synonyms:

Chemical Property of 2H-Isoindole-2-acetamide, N-[(7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-yl)methyl]-1, 3-dihydro-1,3-dioxo-, monohydrochloride

Chemical Property:

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Technology Process of 2H-Isoindole-2-acetamide, N-[(7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-yl)methyl]-1, 3-dihydro-1,3-dioxo-, monohydrochloride

There total 2 articles about 2H-Isoindole-2-acetamide, N-[(7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-yl)methyl]-1, 3-dihydro-1,3-dioxo-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-phthaloylglycine chloride (6780-38-7) + 2-aminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-<1,4>-benzodiazepine dimaleate (138729-69-8) → 2-phthalimidoacetylaminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-1,4-benzodiazepine hydrochloride (138729-70-1)

Guidance literature:

In dichloromethane; benzene; for 2h; Heating;

DOI:10.1002/jhet.5570280704

Reference yield:

N-phthaloylglycine (4702-13-0) → 2-phthalimidoacetylaminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-1,4-benzodiazepine hydrochloride (138729-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / Heating

2: 84 percent / CH₂Cl₂; benzene / 2 h / Heating

With thionyl chloride; In dichloromethane; benzene;

DOI:10.1002/jhet.5570280704

Reference yield: 83.0%

2-phthalimidoacetylaminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-1,4-benzodiazepine hydrochloride (138729-70-1) → 2-phthalimidoacetylaminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-1,4-benzodiazepine (138366-01-5)

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1002/jhet.5570280704

upstream raw materials:

N-phthaloylglycine chloride

2-aminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-<1,4>-benzodiazepine dimaleate

N-phthaloylglycine

Downstream raw materials:

2-phthalimidoacetylaminomethyl-7-chloro-2,3-dihydro-5-phenyl-2H-1,4-benzodiazepine

2-(2-aminoacetamidomethyl)-7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepine

8-chloro-6-phenyl-1-phthalimidomethyl-4H-imidazo<1,5-a><1,4>benzodiazepine

8-chloro-3a,4-dihydro-6-phenyl-1-phthalimidomethyl-3H-imidazo-<1,5-a><1,4>benzodiazepine

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