Chemical Property of N-[(E)-[4-(diethylamino)phenyl]methylideneamino]-4-hydroxybenzamide
Chemical Property:
- Boiling Point:°Cat760mmHg
- Flash Point:°C
- PSA：64.93000
- Density:1.11g/cm3
- LogP:3.39320
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥14 mg/mL
- XLogP3:3.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:6
- Exact Mass:311.16337692
- Heavy Atom Count:23
- Complexity:380
- Purity/Quality:
-
99%, *data from raw suppliers
GSK 4716 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCN(CC)C1=CC=C(C=C1)C=NNC(=O)C2=CC=C(C=C2)O
- Isomeric SMILES:CCN(CC)C1=CC=C(C=C1)/C=N\NC(=O)C2=CC=C(C=C2)O
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Description
DY131 (95167-41-2) is a selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.1?Displays antiproliferative activity in prostate cancer cells.2?Promotes hormone production and cell fusion in cytotrophoblasts.3?In breast cancer cells DY131 arrests cells in G2/M and causes mitotic spindle defects.4?Inhibits osteoclastogenesis and protects against inflammatory bone loss induced by LPS?in vivo.5
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Uses
DY131 is a selective estrogen-related receptors (ERRβ and ERRγ) agonist (1,2). It is also an antimitotic agent that inhibits breast cancer cell growth.
