L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L -2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester

Base Information

Chemical Name:L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L -2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester
CAS No.:138774-78-4
Molecular Formula:C63H72N6O9
Molecular Weight:1057.3
Hs Code.:

L-Proline,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L
-2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester

Synonyms:

Suppliers and Price of L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L -2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L -2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L -2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester

There total 8 articles about L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-L-isoleucyl-D-prolyl-L -2-piperidinecarbonyl-N-methyl-D-phenylalanyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Fmoc-D-Phe-L-Ile-OCH₂Ph

: 138774-78-4
Fmoc-D-Phe-L-Ile-D-Pro-L-Pip-D-(N-Me)Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / H₂ / 10percent Pd/C / ethanol; acetic acid / 760 Torr / Ambient temperature

2: 1.) 4-methylmorpholine, pivaloyl chloride / 1.) CH₃Cl, -20 deg C, 5 h, 2.) CH₃Cl, -20 deg C, 18 h

With 4-methyl-morpholine; hydrogen; pivaloyl chloride; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1021/jm00099a019

Reference yield:

: H-L-Pip-D-(N-Me)Phe-L-Pro-OCH₂Ph

: 138774-78-4
Fmoc-D-Phe-L-Ile-D-Pro-L-Pip-D-(N-Me)Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N,N-diisopropylethylamine (DIEA), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), 2.) N,N-diisopropylethylamine (DIEA) / 1.) CH₂Cl₂, 1.5 h, 2.) CH₂Cl₂, 0 deg C, 16 h

2: diethylamine / acetonitrile / Ambient temperature

3: 1.) 4-methylmorpholine, pivaloyl chloride / 1.) CH₃Cl, -20 deg C, 5 h, 2.) CH₃Cl, -20 deg C, 18 h

With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; pivaloyl chloride; diethylamine; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/jm00099a019

Reference yield:

: 138774-86-4
N-<(9-fluorenylmethoxy)carbonyl>-L-pipecolic acid chloride

: 138774-78-4
Fmoc-D-Phe-L-Ile-D-Pro-L-Pip-D-(N-Me)Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

2: diethylamine / acetonitrile / Ambient temperature

3: 1.) N,N-diisopropylethylamine (DIEA), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), 2.) N,N-diisopropylethylamine (DIEA) / 1.) CH₂Cl₂, 1.5 h, 2.) CH₂Cl₂, 0 deg C, 16 h

4: diethylamine / acetonitrile / Ambient temperature

5: 1.) 4-methylmorpholine, pivaloyl chloride / 1.) CH₃Cl, -20 deg C, 5 h, 2.) CH₃Cl, -20 deg C, 18 h

With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; pivaloyl chloride; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm00099a019