Glycine, N-[N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-D-methionyl]-L-phenylalan yl]-, methyl ester

Base Information

Chemical Name:Glycine, N-[N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-D-methionyl]-L-phenylalan yl]-, methyl ester
CAS No.:138891-24-4
Molecular Formula:C₂₆H₃₃N₃O₇S
Molecular Weight:531.63
Hs Code.:

Synonyms:

Suppliers and Price of Glycine, N-[N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-D-methionyl]-L-phenylalan yl]-, methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-D-methionyl]-L-phenylalan yl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Glycine, N-[N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-D-methionyl]-L-phenylalan yl]-, methyl ester

There total 1 articles about Glycine, N-[N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-D-methionyl]-L-phenylalan yl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65559-51-5
L-Phenylalaninyl-glycine methyl ester

: 82155-46-2
Z(OMe)-D-Met-OH

: 138891-24-4
Z(OMe)-D-Met-Phe-Gly-OMe

Guidance literature:: With triethylamine; Yield given. Multistep reaction; 1) mixed anhydride, 2) DMF, 1.5 h, ice-cooling;
DOI:10.1248/cpb.39.2734

Reference yield:

: 138891-24-4
Z(OMe)-D-Met-Phe-Gly-OMe

: 100572-16-5
H-Tyr-D-Met(O)-Phe-Gly-NH₂

Guidance literature:: Multi-step reaction with 7 steps

1: anisole, ethanedithiol, CF₃CO₂H

2: Et₃N / dimethylformamide / 25 °C

3: 76 percent / 1N NaOH / methanol / 2 h / 0 °C

4: 90 percent / 35percent H₂O₂, AcOH / acetic acid / 1 h / 25 °C

5: 40 percent / DCC / tetrahydrofuran / 12 h / 25 °C

6: CF₃CO₂H, anisole / 1 h / 0 °C

7: 5 percent / 28percent NH₄OH / dimethylformamide / 1 h

With ethandithiol; ammonium hydroxide; sodium hydroxide; dihydrogen peroxide; acetic acid; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2734

Reference yield:

: 138891-24-4
Z(OMe)-D-Met-Phe-Gly-OMe

: 108269-53-0
Boc-Tyr-D-Met-Phe-Gly-OH

Guidance literature:: Multi-step reaction with 3 steps

1: anisole, ethanedithiol, CF₃CO₂H

2: Et₃N / dimethylformamide / 25 °C

3: 76 percent / 1N NaOH / methanol / 2 h / 0 °C

With ethandithiol; sodium hydroxide; methoxybenzene; triethylamine; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2734