Technology Process of Pyridine,
3-methyl-2,6-bis(phenylmethoxy)-5-[4-[(tetrahydro-2H-pyran-2-yl)oxy]but
yl]-
There total 6 articles about Pyridine,
3-methyl-2,6-bis(phenylmethoxy)-5-[4-[(tetrahydro-2H-pyran-2-yl)oxy]but
yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / TosOH*H2O / diethyl ether / 1.) 0 deg C, 2.) -> r.t. during 90 min.
2: 1.) NaH (80percent in paraffin oil) / 1.) DMF, 30 min., 90 deg C, 2.) DMF 90 deg C
With
sodium hydride; toluene-4-sulfonic acid;
In
diethyl ether;
DOI:10.1016/S0040-4020(01)96055-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene / 64 h / 95 °C
2: 1.) NaH (80percent in paraffin oil) / 1.) DMF, 30 min., 90 deg C, 2.) DMF 90 deg C
With
sodium hydride;
In
toluene;
DOI:10.1016/S0040-4020(01)96055-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / 20 h / 80 °C
2: 77 percent / Bu4NF*3H2O / tetrahydrofuran / 0.5 h / Ambient temperature
3: 96 percent / TosOH*H2O / diethyl ether / 1.) 0 deg C, 2.) -> r.t. during 90 min.
4: 1.) NaH (80percent in paraffin oil) / 1.) DMF, 30 min., 90 deg C, 2.) DMF 90 deg C
With
tetrabutyl ammonium fluoride; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4020(01)96055-7
