Dolasetron

Base Information

Chemical Name:Dolasetron
CAS No.:139014-62-3
Molecular Formula:C19H20N2O3
Molecular Weight:
Hs Code.:
European Community (EC) Number:601-402-4,601-404-5
UNII:82WI2L7Q6E
DSSTox Substance ID:DTXSID4048276
Wikipedia:Dolasetron
Wikidata:Q1829318,Q27166396
NCI Thesaurus Code:C61735
RXCUI:68091
Pharos Ligand ID:UHCDNF4QXV1T,UHCQQX86RQ4A
Metabolomics Workbench ID:43057
ChEMBL ID:CHEMBL2368925
Mol file:139014-62-3.mol

Synonyms:1H-indole-3-carboxylic acid, (6R,9AS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, rel-, methanesulfonate, hydrate (1:1:1);1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-;1H-indole-3-carboxylic acid-trans-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester methanesulfonate;Anzemet;dolasetron;dolasetron mesilate monohydrate;dolasetron mesylate;dolasetron mesylate monohydrate;indole-3-carboxylic acid, ester with (8R)-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one;MDL 73,147EF;MDL 73147EF;MDL-73147EF;octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate

Suppliers and Price of Dolasetron

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Dolasetron

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:324.14739250
Heavy Atom Count:24
Complexity:535

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54
Isomeric SMILES:C1[C@@H]2CC(C[C@H]3N2CC(=O)C1C3)OC(=O)C4=CNC5=CC=CC=C54
Recent ClinicalTrials:The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects

Technology Process of Dolasetron

There total 2 articles about Dolasetron which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 143343-85-5,115956-07-5
endo-5-hydroxy-8-azatricyclo[5.3.1.0³,⁸]-undecan-10-one

: 139014-62-3,115956-12-2
indole-3-carboxylic acid octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester

Guidance literature:: 1H-indole-3-carboxylic acid; With trifluoroacetic anhydride; In dichloromethane; at 20 - 25 ℃; for 0.333333h;

endo-5-hydroxy-8-azatricyclo[5.3.1.0³,⁸]-undecan-10-one; dmap; In dichloromethane; at 30 - 35 ℃; for 4h;

With sodium hydrogencarbonate; In dichloromethane; water; Product distribution / selectivity;