4'-HYDROXY-4-METHYLDIPHENYLAMINE

Base Information

• Chemical Name: 4'-HYDROXY-4-METHYLDIPHENYLAMINE
• CAS No.: 29813-87-4
• Molecular Formula: C13H13 N O
• Molecular Weight: 199.252
• Mol file: 29813-87-4.mol

Synonyms:Phenol,p-(p-toluidino)- (6CI,8CI); 4-Hydroxy-4'-methyldiphenylamine;4-[(4-Methylphenyl)amino]phenol; NSC 401137; p-(p-Toluidino)phenol

Chemical Property of 4'-HYDROXY-4-METHYLDIPHENYLAMINE

Chemical Property:

• Vapor Pressure: 2.33E-05mmHg at 25°C
• Boiling Point: 349.5°Cat760mmHg
• Flash Point: 143.5°C
• PSA: 32.26000
• Density: 1.17g/cm³
• LogP: 3.51720

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-HYDROXY-4-METHYLDIPHENYLAMINE

There total 18 articles about 4'-HYDROXY-4-METHYLDIPHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

para-bromotoluene (106-38-7) + 4-amino-phenol (123-30-8) → N-(4-hydroxyphenyl)-p-toluidine (29813-87-4)

Guidance literature:

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ll); sodium t-butanolate; In 1,4-dioxane; at 110 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja9081815

Reference yield: 85.0%

p-toluidine (106-49-0,12221-03-3) + hydroquinone (123-31-9,8027-02-9) → N-(4-hydroxyphenyl)-p-toluidine (29813-87-4)

Guidance literature:

With alumina; at 270 ℃; for 3h; under 15001.5 Torr; Autoclave; Inert atmosphere;

Reference yield: 78.0%

4-bromo-phenol (106-41-2) + p-toluidine (106-49-0,12221-03-3) → N-(4-hydroxyphenyl)-p-toluidine (29813-87-4)

Guidance literature:

With lithium hexamethyldisilazane; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane; palladium diacetate; In tetrahydrofuran; toluene; at 80 ℃; for 28h;

DOI:10.1002/adsc.200404005

upstream raw materials:

N-(4-Methylphenyl)-1,4-benzoquinone monoimine

p-toluidine

hydroquinone

p-methylazidobenzene

Downstream raw materials:

(4-pentyloxy-phenyl)-p-tolyl-amine

N-(4-Methylphenyl)-1,4-benzoquinone monoimine

4-methoxy-N-methyl-N-(p-tolyl)aniline

2-(4-p-toluidino-phenoxy)-ethanol