2-Quinolinecarboxylic acid, 4-broMo-, Methyl ester 97%

Base Information

• Chemical Name: 2-Quinolinecarboxylic acid, 4-broMo-, Methyl ester 97%
• CAS No.: 139896-91-6
• Molecular Formula: C11H8BrNO2
• Molecular Weight: 266.09100
• Mol file: 139896-91-6.mol

Synonyms:methyl 3-phenyl-1,2-thiazetidine-2-carboxylate 1,1-dioxide;methyl 4-bromoquinoline-2-carboxylate;2-carbomethoxy-4-bromoquinoline;2-Carbomethoxy-3-phenyl-1,2-thiazetidin-1,1-dioxid;

Chemical Property of 2-Quinolinecarboxylic acid, 4-broMo-, Methyl ester 97%

Chemical Property:

• PSA: 39.19000
• LogP: 2.78390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Quinolinecarboxylic acid, 4-broMo-, Methyl ester 97%

There total 4 articles about 2-Quinolinecarboxylic acid, 4-broMo-, Methyl ester 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methoxy quinoline-2-carboxylic acid methyl ester (67976-94-7) → methyl 4-bromoquinoline-2-carboxylate (139896-91-6)

Guidance literature:

With phosphorus tribromide; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

DOI:10.1021/jm00088a014

Reference yield: 73.0%

4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester (7101-89-5,5965-59-3) → methyl 4-bromoquinoline-2-carboxylate (139896-91-6)

Guidance literature:

With potassium carbonate; phosphorus(V) oxybromide; In acetonitrile; for 3h; Reflux;

DOI:10.1002/jhet.5570450520

Reference yield: 50.0%

4-hydroxyquinoline-2-carboxylic acid methyl ester (5965-59-3) → methyl 4-bromoquinoline-2-carboxylate (139896-91-6)

Guidance literature:

4-hydroxyquinoline-2-carboxylic acid methyl ester; With phosphorus pentoxide; tetrabutylammomium bromide; In toluene; at 100 ℃; for 2h;

With sodium hydrogencarbonate; In water; toluene;

upstream raw materials:

4-methoxy quinoline-2-carboxylic acid methyl ester

4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester

4-hydroxyquinoline-2-carboxylic acid methyl ester

kinurenic acid

Downstream raw materials:

methyl 4-(3-chlorophenyl)quinoline-2-carboxylate

methyl 4-(4-chlorophenyl)quinoline-2-carboxylate

methyl 4-(2-chlorophenyl)quinoline-2-carboxylate

4-phenyl-quinoline-2-carboxylic acid methyl ester