ETHYL 2-NITRILO-2-(2-OXOINDOLIN-3-YLIDENE)ACETATE

Base Information

• Chemical Name: ETHYL 2-NITRILO-2-(2-OXOINDOLIN-3-YLIDENE)ACETATE
• CAS No.: 14003-19-1
• Molecular Formula: C13H10N2O3
• Molecular Weight: 242.23000
• Hs Code.: 2915390090
• Mol file: 14003-19-1.mol

Synonyms:ethyl 2-(2-oxo-(3H)-indol-3-ylidene)cyanoacetate;Cyano-[2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid ethyl ester;ethyl (E)-2-oxo-3-indolinylidenecyanoacetate;

Chemical Property of ETHYL 2-NITRILO-2-(2-OXOINDOLIN-3-YLIDENE)ACETATE

Chemical Property:

• PSA: 79.19000
• LogP: 1.61698

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Nitrilo-2-(2-oxoindolin-3-ylidene)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 2-NITRILO-2-(2-OXOINDOLIN-3-YLIDENE)ACETATE

There total 7 articles about ETHYL 2-NITRILO-2-(2-OXOINDOLIN-3-YLIDENE)ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate (14003-18-0,14003-19-1,59225-18-2)

Guidance literature:

With aluminum oxide; In methanol; at 20 ℃; for 0.333333h;

DOI:10.3987/COM-08-11504

Reference yield: 20.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + ethyl 2-cyanoacetate (105-56-6) → ethyl cyano-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)acetate (14003-19-1)

Guidance literature:

With piperidine; In ethanol; at 78 ℃; for 2h;

DOI:10.1016/j.tetlet.2018.06.009

Reference yield:

triphenylphosphorane (13504-72-8) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate (14003-18-0,14003-19-1,59225-18-2)

Guidance literature:

In dichloromethane; at 0 ℃; for 8h;

DOI:10.1016/j.tet.2016.04.037

upstream raw materials:

indole-2,3-dione

ethyl 2-cyanoacetate

triphenylphosphorane

3-methylene-2-indolinone

Downstream raw materials:

Cyano-(2-oxo-2,3-dihydro-1H-indol-3-yl)-phenylsulfanyl-acetic acid ethyl ester

Benzylsulfanyl-cyano-(2-oxo-2,3-dihydro-1H-indol-3-yl)-acetic acid ethyl ester

3-(2-phenylhydrazono)indolin-2-one

ethyl 6′-amino-3′-methyl-2-oxo-1′-phenyl-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carboxylate