Technology Process of L-Glutamic acid,
N-[4-[[(1,4-dihydro-4-oxo-1,2,3-benzotriazin-6-yl)methyl]amino]benzoyl]-
, dimethyl ester
There total 4 articles about L-Glutamic acid,
N-[4-[[(1,4-dihydro-4-oxo-1,2,3-benzotriazin-6-yl)methyl]amino]benzoyl]-
, dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; sodium hydrogencarbonate; acetic acid;
Yield given. Multistep reaction;
1.) 70 deg C, 2 h, irrad, 2.) DMF, 65 deg C, 3 days;
DOI:10.1021/jm00092a013
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) SOCl2, 2.) NaOH, NH4OH / 1.) reflux, 20 min, 2.) THF
2: 96 percent / H2 / 5percent Pd/C / methanol / 24 h / 2280 Torr
3: 97 percent / 3.6 N aq. HCl, NaNO2 / H2O / 0.33 h / 5 °C
4: 1.) N-bromosuccinimide, glacial acetic acid, 2.) NaHCO3 / 1.) 70 deg C, 2 h, irrad, 2.) DMF, 65 deg C, 3 days
With
hydrogenchloride; ammonium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; hydrogen; sodium hydrogencarbonate; acetic acid; sodium nitrite;
palladium on activated charcoal;
In
methanol; water;
DOI:10.1021/jm00092a013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / H2 / 5percent Pd/C / methanol / 24 h / 2280 Torr
2: 97 percent / 3.6 N aq. HCl, NaNO2 / H2O / 0.33 h / 5 °C
3: 1.) N-bromosuccinimide, glacial acetic acid, 2.) NaHCO3 / 1.) 70 deg C, 2 h, irrad, 2.) DMF, 65 deg C, 3 days
With
hydrogenchloride; N-Bromosuccinimide; hydrogen; sodium hydrogencarbonate; acetic acid; sodium nitrite;
palladium on activated charcoal;
In
methanol; water;
DOI:10.1021/jm00092a013
