Pydine

Base Information

• Chemical Name: Pydine
• CAS No.: 280-75-1
• Molecular Formula: C7H13 N O
• Molecular Weight: 127.18
• Hs Code.: 2934999090
• Mol file: 280-75-1.mol

Synonyms:Pydine

Chemical Property of Pydine

Chemical Property:

• Boiling Point: 200.2±33.0 °C(Predicted)
• PKA: 10.42±0.20(Predicted)
• PSA: 21.26000
• Density: 0.995±0.06 g/cm3(Predicted)
• LogP: 0.57110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3-Oxa-7-azabicyclo[3.3.1]nonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pydine

There total 7 articles about Pydine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

7-benzyl-3-oxa-7-aza-bicyclo[3.3.1]nonane (77716-06-4) → 3-oxa-7-azabicyclo[3.3.1]nonane (280-75-1)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 1h; Heating;

DOI:10.1080/00304949909355730

Reference yield:

7-(tert-butyloxycarbonyl)-3-oxa-7-azabicyclo[3.3.1]nonane (454695-27-3) → 3-oxa-7-azabicyclo[3.3.1]nonane (280-75-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1039/b200454b DOI:10.1002/1521-3765(20021018)8:20<4767::AID-CHEM4767>3.0.CO;2-O

Reference yield:

7-benzyl-3-oxa-7-azabicyclo<3.3.1>nonan-9-one (77716-01-9) → 3-oxa-7-azabicyclo[3.3.1]nonane (280-75-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ClCOOCH(Cl)CH₃ / CH₂Cl₂ / 2 h / Heating

1.2: MeOH / 1 h / Heating

2.1: 456 mg / aq. KOH / dioxane / 12 h / 20 °C

3.1: p-TsOH / dimethylformamide / 0.17 h / 100 °C

4.1: 108 mg / NaBH₃CN / dimethylformamide / 2 h / 100 °C

5.1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; sodium cyanoborohydride; toluene-4-sulfonic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/1521-3765(20021018)8:20<4767::AID-CHEM4767>3.0.CO;2-O

upstream raw materials:

7-benzyl-3-oxa-7-aza-bicyclo[3.3.1]nonane

7-(tert-butyloxycarbonyl)-3-oxa-7-azabicyclo[3.3.1]nonane

Tetrahydro-4H-pyran-4-one

7-benzyl-3-oxa-7-azabicyclo<3.3.1>nonan-9-one

Downstream raw materials:

7-(4-nitro-benzenesulfonyl)-3-oxa-7-aza-bicyclo[3.3.1]nonane

(4-fluoro-phenyl)-(3-oxa-7-aza-bicyclo[3.3.1]non-7-yl)-methanone