Cholestan-26-oic acid, 3,7-bis(acetyloxy)-12-[[(4-methylphenyl)sulfonyl]hydrazono]-, methyl ester, (3a,5b,7a,25R)-

Base Information

• Chemical Name: Cholestan-26-oic acid, 3,7-bis(acetyloxy)-12-[[(4-methylphenyl)sulfonyl]hydrazono]-, methyl ester, (3a,5b,7a,25R)-
• CAS No.: 141417-50-7
• Molecular Formula: C₃₉H₅₈N₂O₈S
• Molecular Weight: 714.964
• Mol file: 141417-50-7.mol

Synonyms:

Chemical Property of Cholestan-26-oic acid, 3,7-bis(acetyloxy)-12-[[(4-methylphenyl)sulfonyl]hydrazono]-, methyl ester, (3a,5b,7a,25R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cholestan-26-oic acid, 3,7-bis(acetyloxy)-12-[[(4-methylphenyl)sulfonyl]hydrazono]-, methyl ester, (3a,5b,7a,25R)-

There total 8 articles about Cholestan-26-oic acid, 3,7-bis(acetyloxy)-12-[[(4-methylphenyl)sulfonyl]hydrazono]-, methyl ester, (3a,5b,7a,25R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(25R)-3α,7α,12α-trihydroxy-5β-cholestane-26-oic acid (23740-14-9) → C39H58N2O8S (141417-50-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄

2: pyridine / benzene / 18 h / Ambient temperature

3: CrO₃, aq. H₂SO₄ / acetone / 0.5 h / Ambient temperature

4: acetic acid / 18 h / Ambient temperature

With pyridine; chromium(VI) oxide; sulfuric acid; In acetic acid; acetone; benzene;

DOI:10.1016/0039-128X(92)90002-Q

Reference yield:

(25R)-methyl 3α,7α,12α-trihydroxy-5β-cholestan-26-oate (23740-22-9) → C39H58N2O8S (141417-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / benzene / 18 h / Ambient temperature

2: CrO₃, aq. H₂SO₄ / acetone / 0.5 h / Ambient temperature

3: acetic acid / 18 h / Ambient temperature

With pyridine; chromium(VI) oxide; sulfuric acid; In acetic acid; acetone; benzene;

DOI:10.1016/0039-128X(92)90002-Q

Reference yield:

Trihydroxycholestanoic acid (547-98-8) → methyl 3α,7α-diacetoxy-12-oxo-5β-cholestan-26-oate-12-tosylhydrazone (141417-49-4,141417-50-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄

2: 420 mg / pyridine / benzene / 18 h / Ambient temperature

3: 340 mg / CrO₃, aq. H₂SO₄ / acetone / 0.5 h / Ambient temperature

4: 230 mg / acetic acid / 18 h / Ambient temperature

With pyridine; chromium(VI) oxide; sulfuric acid; In acetic acid; acetone; benzene;

DOI:10.1016/0039-128X(92)90002-Q

upstream raw materials:

methyl 3α,7α-diacetoxy-12-oxo-5β-cholestan-26-oate

toluene-4-sulfonic acid hydrazide

Trihydroxycholestanoic acid

(R)-2-Methyl-6-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-heptanoic acid methyl ester

Downstream raw materials:

(25RS)-3α,7α-dihydroxy-5β-cholestan-26-oic acid