4alpha-Phorbol 12,13-didecanoate

Base Information

Chemical Name:4alpha-Phorbol 12,13-didecanoate
CAS No.:27536-56-7
Molecular Formula:C₄₀H₆₄O₈
Molecular Weight:672.943
Hs Code.:
European Community (EC) Number:636-676-4
DSSTox Substance ID:DTXSID901098483
Nikkaji Number:J341.547C
Wikidata:Q27073750
Pharos Ligand ID:Z1X87FDK1AMD
ChEMBL ID:CHEMBL118987
Mol file:27536-56-7.mol

Synonyms:4alpha-Phorbol 12,13-didecanoate;27536-56-7;4alphaPDD;4alpha-PDD;4Alpha-Phorbol-Didecanoate;4alpha-Phorbol-12,13-didecanoate;CHEMBL118987;4|A-Phorbol 12,13-didecanoate;4alpha-Phorbol 12,13-dideconate;4-alpha-Phorbol 12,13-didecanoate;[(1S,2S,6S,10S,11R,13S,14R,15R)-13-decanoyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] decanoate;Decanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4aalpha,7aalpha,7balpha,8alpha,9beta,9aalpha))-;D09OHS;4-.alpha.-Phorbol didecanoate;4-Phorbol 12,13-didecanoate;GTPL2500;[decanoyloxy-dihydroxy-(hydroxymethyl)-tetramethyl-oxo-[?]yl] decanoate;4a-Phorbol-12,13-didecanoate;CHEBI:139299;12,13-didecanoyl-4alpha-phorbol;DTXSID901098483;C40H64O8;CBA53656;4+/--Phorbol 12,13-didecanoate;BDBM50240777;4 alpha -Phorbol 12,13-didecanoate;AKOS040747628;C40-H64-O8;4-.alpha.-Phorbol 12,13-didecanoate;4alpha-Phorbol 12,13-didecanoate, solid;HY-116291;J-016805;Q27073750;4alpha-Phorbol-12,13-didecanoate - CAS 27536-56-7;(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl didecanoate;1,1'-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] didecanoate;Decanoic acid (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9-decanoyloxy-4a,7b-dihydroxy-3-hydroxymethyl-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl ester;Decanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester;Decanoic acid, 1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1a.alpha.,1b.beta.,4a.alpha.,7a.alpha.,7b.alpha.,8.alpha.,9.beta.,9a.alpha.)]-;Decanoic acid, 9,9a-diester with 1,1a.alpha.,1b.beta.,4,4a,7a.alpha.,7b,8,9,9a-decahydro-4a.alpha.,7b.alpha.,9.beta.,9a.alpha.-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8.alpha.-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one;decanoicacid,1,1'-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl]ester

Suppliers and Price of 4alpha-Phorbol 12,13-didecanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
4-alpha-Phorbol 12,13-Didecanoate
1mg
$ 237.00

TRC
4α-Phorbol 12,13-didecanoate
1mg
$ 220.00

Sigma-Aldrich
4α-Phorbol 12,13-didecanoate solid
1mg
$ 171.00

Sigma-Aldrich
4α-Phorbol-12,13-didecanoate
1mg
$ 97.12

Sigma-Aldrich
4α-Phorbol-12,13-didecanoate
5mg
$ 369.07

Sigma-Aldrich
4α-Phorbol 12,13-didecanoate solid
5mg
$ 642.00

Medical Isotopes, Inc.
4?±-Phorbol12,13-Didecanoate >99%
1 mg
$ 370.00

Cayman Chemical
4α-Phorbol 12,13-didecanoate ≥99%
5mg
$ 363.00

Cayman Chemical
4α-Phorbol 12,13-didecanoate ≥99%
1mg
$ 86.00

American Custom Chemicals Corporation
4ALPHA-PHORBOL 12,13-DIDECANOATE 95.00%
5MG
$ 917.54

Total 13 raw suppliers

Chemical Property of 4alpha-Phorbol 12,13-didecanoate

Chemical Property:

Vapor Pressure:6.92E-25mmHg at 25°C
Boiling Point:734.2°Cat760mmHg
Flash Point:212.4°C
PSA：130.36000
Density:1.14g/cm³
LogP:7.31330
Storage Temp.:−20°C
Solubility.:DMSO: soluble
XLogP3:8.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:21
Exact Mass:672.46011900
Heavy Atom Count:48
Complexity:1220

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-alpha-Phorbol 12,13-Didecanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T+
Statements: 26/27/28-40-43
Safety Statements: 36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)CCCCCCCCC)O)C
Isomeric SMILES:CCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)CCCCCCCCC)O)C
Uses 4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:to study its effects on Madin-Darby canine kidney (MDCK) cellsto study its effects on Ca2+ influx in mice fallopian tubal cellsto study its effects on hind paw swelling in mice

Technology Process of 4alpha-Phorbol 12,13-didecanoate

There total 2 articles about 4alpha-Phorbol 12,13-didecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: