Carbonic acid, 1-(1,1-difluoro-2-hydroxyethyl)dodecyl phenylmethyl ester, (R)-

Base Information

Chemical Name:Carbonic acid, 1-(1,1-difluoro-2-hydroxyethyl)dodecyl phenylmethyl ester, (R)-
CAS No.:141458-98-2
Molecular Formula:C22H34F2O4
Molecular Weight:400.506
Hs Code.:
Mol file:141458-98-2.mol

Synonyms:

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Chemical Property of Carbonic acid, 1-(1,1-difluoro-2-hydroxyethyl)dodecyl phenylmethyl ester, (R)-

Chemical Property:

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Technology Process of Carbonic acid, 1-(1,1-difluoro-2-hydroxyethyl)dodecyl phenylmethyl ester, (R)-

There total 12 articles about Carbonic acid, 1-(1,1-difluoro-2-hydroxyethyl)dodecyl phenylmethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141458-97-1
(R)-3-<(benzyloxycarbonyl)oxy>-1-<(tert-butyldimethylsilyl)oxy>-2,2-(difluoro)tetradecane

: 141458-98-2
(R)-3-<(benzyloxycarbonyl)oxy>-2,2-difluoro-1-hydroxytetradecane

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 - 27 ℃; for 16h; Yield given;
DOI:10.1016/S0957-4166(00)80289-X

Reference yield:

: 23339-18-6,34339-61-2,34340-42-6,61278-06-6,132074-93-2
methyl 2,3-dideoxy-α-D-threo-hexopyranoside

: 141458-98-2
(R)-3-<(benzyloxycarbonyl)oxy>-2,2-difluoro-1-hydroxytetradecane

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / NaH / tetrahydrofuran / 16 h / 20 - 25 °C

2: 93 percent / 0.5percent aq. H₂SO₄ / dioxane / 1 h / 75 - 80 °C

3: 58 percent / tetrahydrofuran; hexane / 0.5 h / 24 °C

4: 72 percent / CrO₃, H₂SO₄ / acetone / 0.5 h / 0 - 5 °C

5: 56 percent / Et₂NSF₃ / CH₂Cl₂ / 16 h / Ambient temperature

6: H₂, AcOH / 10percent Pd/C / 5 h

7: H₂ / 20percent Pd(OH)2/C / ethanol / 12 h / 20 - 24 °C

8: 80 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 16 h / 25 °C

9: 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) RT, 3 h

10: conc. aq. HCl / dioxane / 16 h / 25 - 27 °C

With chromium(VI) oxide; hydrogenchloride; dmap; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; sodium hydride; acetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; acetone;
DOI:10.1016/S0957-4166(00)80289-X

Reference yield:

: 131985-35-8
methyl 4,6-di-O-benzyl-2,3-dideoxy-α-D-threo-hexopyranoside

: 141458-98-2
(R)-3-<(benzyloxycarbonyl)oxy>-2,2-difluoro-1-hydroxytetradecane

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / 0.5percent aq. H₂SO₄ / dioxane / 1 h / 75 - 80 °C

2: 58 percent / tetrahydrofuran; hexane / 0.5 h / 24 °C

3: 72 percent / CrO₃, H₂SO₄ / acetone / 0.5 h / 0 - 5 °C

4: 56 percent / Et₂NSF₃ / CH₂Cl₂ / 16 h / Ambient temperature

5: H₂, AcOH / 10percent Pd/C / 5 h

6: H₂ / 20percent Pd(OH)2/C / ethanol / 12 h / 20 - 24 °C

7: 80 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 16 h / 25 °C

8: 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) RT, 3 h

9: conc. aq. HCl / dioxane / 16 h / 25 - 27 °C

With chromium(VI) oxide; hydrogenchloride; dmap; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; acetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; acetone;
DOI:10.1016/S0957-4166(00)80289-X