6,10-Dioxaspiro[4.5]dec-3-ene-1,3-dicarboxylic acid, 1-cyano-2-methoxy-8,8-dimethyl-4-phenyl-, 1-methyl 3-(1-methylethyl) ester

Base Information

Chemical Name:6,10-Dioxaspiro[4.5]dec-3-ene-1,3-dicarboxylic acid, 1-cyano-2-methoxy-8,8-dimethyl-4-phenyl-, 1-methyl 3-(1-methylethyl) ester
CAS No.:141508-90-9
Molecular Formula:C24H29NO7
Molecular Weight:443.497
Hs Code.:
Mol file:141508-90-9.mol

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Chemical Property of 6,10-Dioxaspiro[4.5]dec-3-ene-1,3-dicarboxylic acid, 1-cyano-2-methoxy-8,8-dimethyl-4-phenyl-, 1-methyl 3-(1-methylethyl) ester

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Technology Process of 6,10-Dioxaspiro[4.5]dec-3-ene-1,3-dicarboxylic acid, 1-cyano-2-methoxy-8,8-dimethyl-4-phenyl-, 1-methyl 3-(1-methylethyl) ester

There total 2 articles about 6,10-Dioxaspiro[4.5]dec-3-ene-1,3-dicarboxylic acid, 1-cyano-2-methoxy-8,8-dimethyl-4-phenyl-, 1-methyl 3-(1-methylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 55883-89-1
methoxymethylenecyanoacetic acid methyl ester

: 141508-81-8
6,6-Dimethyl-2-phenyl-4,8-dioxa-spiro[2.5]oct-1-ene-1-carboxylic acid isopropyl ester

: 141508-90-9
5-cyano-3-(isopropoxycarbonyl)-4-methoxy-5-(methoxycarbonyl)-2-phenylcyclopent-2-enone 1,3-(2,2-dimethyl)propanediyl acetal

Guidance literature:: In tetrahydrofuran; hexane; at 0 - 25 ℃; for 24h;
DOI:10.1021/ja00040a006

Reference yield:

: 122762-89-4
2-phenylcyclopropenone 2,2-dimethyl-1,3-propanediyl acetal

: 141508-90-9
5-cyano-3-(isopropoxycarbonyl)-4-methoxy-5-(methoxycarbonyl)-2-phenylcyclopent-2-enone 1,3-(2,2-dimethyl)propanediyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HMPA, BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 5 h

2: 78 percent / tetrahydrofuran; hexane / 24 h / 0 - 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/ja00040a006