1H,5H-Pyrazolo[1,2-a][1,2]diazepine-5-carboxylic acid, 7-chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-, methyl ester

Base Information

Chemical Name:1H,5H-Pyrazolo[1,2-a][1,2]diazepine-5-carboxylic acid, 7-chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-, methyl ester
CAS No.:141514-50-3
Molecular Formula:C₁₈H₂₃ClN₂O₃
Molecular Weight:350.845
Hs Code.:
Mol file:141514-50-3.mol

Synonyms:

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Chemical Property of 1H,5H-Pyrazolo[1,2-a][1,2]diazepine-5-carboxylic acid, 7-chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-, methyl ester

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Technology Process of 1H,5H-Pyrazolo[1,2-a][1,2]diazepine-5-carboxylic acid, 7-chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-, methyl ester

There total 7 articles about 1H,5H-Pyrazolo[1,2-a][1,2]diazepine-5-carboxylic acid, 7-chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 141514-51-4
α-Acetoxy-5,5-dimethyl-3-oxo-1-(1-phenyl-3-butenyl)-3-pyrazolidineacetic acid methyl ester

: 141514-50-3
7-Chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-1H,5H-pyrazolo<1,2-a><1,2>diazepine-5-carboxylic acid methyl ester

Guidance literature:: With tin(IV) chloride;

Reference yield:

: 141514-37-6
5,5-Dimethyl-1-(1-phenyl-3-butenyl)-3-pyrazolidinone

: 141514-50-3
7-Chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-1H,5H-pyrazolo<1,2-a><1,2>diazepine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / Ambient temperature

2: DMAP, pyridine / 18 h / Ambient temperature

3: 18 percent / SnCl₄ / CH₂Cl₂ / 1.) -78 deg C, 15 min, 2.) r.t.

With pyridine; dmap; tin(IV) chloride; In dichloromethane; benzene;
DOI:10.1002/recl.19941130304

Reference yield:

: 42953-82-2
5,5-dimethylpyrazolidin-3-one

: 141514-50-3
7-Chlorohexahydro-1,1-dimethyl-3-oxo-9-phenyl-1H,5H-pyrazolo<1,2-a><1,2>diazepine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / p-TSA / toluene / 18 h / Heating

2: 45 percent / tetrahydrofuran / 1.) r.t., 2 h, 2.) reflux, 1 h

3: benzene / Ambient temperature

4: DMAP, pyridine / 18 h / Ambient temperature

5: 18 percent / SnCl₄ / CH₂Cl₂ / 1.) -78 deg C, 15 min, 2.) r.t.

With pyridine; dmap; tin(IV) chloride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene; benzene;
DOI:10.1002/recl.19941130304