Technology Process of 1-Pyrrolidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester, (S)-
There total 30 articles about 1-Pyrrolidinecarboxylic acid, 2-ethenyl-, phenylmethyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; allyl (R)-6-(2-chloronaphthalen-1-yl)-5-methylpyridine-2-carboxylate;
In
N,N-dimethyl acetamide;
at 100 ℃;
for 3h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol203218d
- Guidance literature:
-
With
triphenylphosphine;
RhCl(PPh3)3;
In
tetrahydrofuran; isopropyl alcohol;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: methanol / 3 h / Inert atmosphere; Reflux
2: 1H-imidazole / dichloromethane / 0.33 h / 20 °C / Inert atmosphere
3: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C / Inert atmosphere
4: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
5: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere
6: cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; allyl (R)-6-(2-chloronaphthalen-1-yl)-5-methylpyridine-2-carboxylate / N,N-dimethyl acetamide / 3 h / 100 °C / Inert atmosphere
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; allyl (R)-6-(2-chloronaphthalen-1-yl)-5-methylpyridine-2-carboxylate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/ol203218d
