Glycyl-L-threonine

Base Information

• Chemical Name: Glycyl-L-threonine
• CAS No.: 27174-15-8
• Molecular Formula: C₆H₁₂N₂O₄
• Molecular Weight: 176.172
• Hs Code.: 2924199090
• European Community (EC) Number: 230-399-9
• Nikkaji Number: J149.620D
• Wikidata: Q27144243
• ChEMBL ID: CHEMBL420983
• Mol file: 27174-15-8.mol

Synonyms:Gly-Thr;glycyl-threonine

Chemical Property of Glycyl-L-threonine

Chemical Property:

• Boiling Point: 486.7°Cat760mmHg
• PKA: 2.98±0.10(Predicted)
• Flash Point: 248.2°C
• PSA: 115.64000
• Density: 1.354g/cm³
• LogP: -0.31070
• Storage Temp.: -15°C
• XLogP3: -4.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 176.07970687
• Heavy Atom Count: 12
• Complexity: 182

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycyl-DL-threonine Hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+,C
• Hazard Codes: T+,C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C(=O)O)NC(=O)CN)O
• Isomeric SMILES: C[C@H]([C@@H](C(=O)O)NC(=O)CN)O

Technology Process of Glycyl-L-threonine

There total 2 articles about Glycyl-L-threonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-chloroacetyl-L-threonine (153893-46-0) → glycyl-DL-threonine (7093-70-1,7361-42-4,27174-15-8)

Guidance literature:

With ammonium hydroxide;

Reference yield:

C6H12N2O4*H(1+) → glycyl-DL-threonine (7093-70-1,7361-42-4,27174-15-8)

Guidance literature:

With nitric acid; potassium nitrate; In water; at 24.99 ℃; Concentration; Thermodynamic data;

DOI:10.1134/S0036024416110078

Reference yield: 67.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + glycyl-DL-threonine (27174-15-8) → N-benzyloxycarbonylglycyl-DL-threonine (40356-00-1,40356-06-7,146767-21-7)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water;

DOI:10.1039/ft9938902761

upstream raw materials:

N-chloroacetyl-L-threonine

Downstream raw materials:

N-benzyloxycarbonylglycyl-DL-threonine

N-benzyloxycarbonylglycyl-DL-threonylglycine benzyl ester

Refernces