U-63557A

Base Information

• Chemical Name: U-63557A
• CAS No.: 85666-17-7
• Molecular Formula: C₁₅H₁₀NO₃*Na
• Molecular Weight: 275.239
• Mol file: 85666-17-7.mol

Synonyms:sodium styrene sulfonate;sodium styrene-4-sulphonate;Styrene-4-sulfonic acid sodium salt;Sodium p-Styrenesulfonate;4-Vinylbenzenesulfonic acid sodium salt;sodium styrene sulphonate;sodium 4-styrenesulfonate;p-styrenesulfonic acid sodium salt;Sodium 4-vinylbenzenesulfonate;

Chemical Property of U-63557A

Chemical Property:

• Vapor Pressure: 3.28E-09mmHg at 25°C
• Boiling Point: 458.7°Cat760mmHg
• Flash Point: 231.2°C
• PSA: 66.16000
• Density: g/cm³
• LogP: 1.78210
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water at approximately 15mg/ml

Purity/Quality:

99% ^*data from raw suppliers

Furegrelate Sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Furegrelate Sodium (U-63557A) is a selective and potent thromboxane A2 synthase (TXA2R) inhibitor in platelets.

Technology Process of U-63557A

There total 5 articles about U-63557A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(3-pyridylmethyl)benzofuran-2-carboxylic acid ethyl ester (85666-16-6) → furegrelate sodium (85666-17-7)

Guidance literature:

With sodium hydroxide; In methanol; for 1.5h;

DOI:10.1021/jm00158a024

Reference yield:

3-(4'-nitrobenzyl)pyridine (32361-76-5) → furegrelate sodium (85666-17-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / H₂ / 10percent Pd/C / methanol / 1 h

2: 1.) NaNO₂, conc H₂SO₄, 2.) H₂O / 1.) water, 1 h, 2.) 160 deg C, 10 min

3: 1.) trifluoroacetic acid, 2.) water / 1.) 80 deg C, 4 h, 2.) RT, 20 min

4: 82 percent / NaH, dicyclohexyl-18-crown-6 / toluene / 48 h / Ambient temperature

5: 95 percent / 0.1N aq. NaOH / methanol / 1.5 h

With perhydrodibenzo-18-crown-6; sodium hydroxide; sulfuric acid; water; hydrogen; sodium hydride; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In methanol; toluene;

DOI:10.1021/jm00158a024

Reference yield:

4-(3'-Pyridinylmethyl)aniline (85666-15-5) → furegrelate sodium (85666-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaNO₂, conc H₂SO₄, 2.) H₂O / 1.) water, 1 h, 2.) 160 deg C, 10 min

2: 1.) trifluoroacetic acid, 2.) water / 1.) 80 deg C, 4 h, 2.) RT, 20 min

3: 82 percent / NaH, dicyclohexyl-18-crown-6 / toluene / 48 h / Ambient temperature

4: 95 percent / 0.1N aq. NaOH / methanol / 1.5 h

With perhydrodibenzo-18-crown-6; sodium hydroxide; sulfuric acid; water; sodium hydride; trifluoroacetic acid; sodium nitrite; In methanol; toluene;

DOI:10.1021/jm00158a024

upstream raw materials:

5-(3-pyridylmethyl)benzofuran-2-carboxylic acid ethyl ester

3-(4'-nitrobenzyl)pyridine

4-(3'-Pyridinylmethyl)aniline

3-(4'-Hydroxybenzyl)pyridine

Refernces