Technology Process of 2H-1,4-Benzoxazine-8-carboxylic acid,
6-chloro-3,4-dihydro-3-oxo-4-(2-phenylethyl)-
There total 6 articles about 2H-1,4-Benzoxazine-8-carboxylic acid,
6-chloro-3,4-dihydro-3-oxo-4-(2-phenylethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
ethanol;
for 3h;
Heating;
DOI:10.1248/cpb.40.624
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 86 percent / HNO3, conc. H2SO4 / 1 h / 0 - 5 °C
2: 79 percent / 0.78N aq. NH4Cl, Fe / toluene / 1 h / 85 - 90 °C
3: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C
4: K2CO3 / dimethylformamide / 2 h / 70 °C
5: 64 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h
6: 90 percent / 5percent NaOH / ethanol / 3 h / Heating
With
sodium hydroxide; sulfuric acid; nitric acid; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride;
In
ethanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.624
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C
2: K2CO3 / dimethylformamide / 2 h / 70 °C
3: 64 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h
4: 90 percent / 5percent NaOH / ethanol / 3 h / Heating
With
sodium hydroxide; sodium hydrogencarbonate; potassium carbonate;
In
ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.624