2-Piperidinecarbonitrile, 4-[2-oxo-5-(phenylmethoxy)pentyl]-1-(phenylmethyl)-, trans-

Base Information

Chemical Name:2-Piperidinecarbonitrile, 4-[2-oxo-5-(phenylmethoxy)pentyl]-1-(phenylmethyl)-, trans-
CAS No.:141764-68-3
Molecular Formula:C₂₅H₃₀N₂O₂
Molecular Weight:390.525
Hs Code.:

Synonyms:

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Chemical Property of 2-Piperidinecarbonitrile, 4-[2-oxo-5-(phenylmethoxy)pentyl]-1-(phenylmethyl)-, trans-

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Technology Process of 2-Piperidinecarbonitrile, 4-[2-oxo-5-(phenylmethoxy)pentyl]-1-(phenylmethyl)-, trans-

There total 5 articles about 2-Piperidinecarbonitrile, 4-[2-oxo-5-(phenylmethoxy)pentyl]-1-(phenylmethyl)-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54555-84-9
benzyl iodoethyl ether

: 141764-68-3
trans-1-Benzyl-4-(5-benzyloxy-2-oxopentyl)piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: ) NaH; 2) nBuLi / 1) THF, room temp., 2 h; 2) hexane, 0 deg C, 30 min; 3) THF, room temp., 1 h

2: 88 percent / potassium hydroxide / ethanol; H₂O / 4 h / Ambient temperature

3: 81 percent / hydrogen / platinum oxide / ethanol / 760 Torr / Ambient temperature

4: 1) m-chloroperoxybenzoic acid; 2) trifluoroacetic anhydride; 3) NaOAc / 1) CH₂Cl₂, 0 deg C, 1 h; 2) CH₂Cl₂, a) -15 deg C, 1 h, b) room temp., 1h; 3) H₂O, CH₂Cl₂, room temp., 30 min

With potassium hydroxide; n-butyllithium; hydrogen; sodium acetate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; platinum(IV) oxide; In ethanol; water;
DOI:10.1016/S0040-4020(01)92254-9

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 141764-68-3
trans-1-Benzyl-4-(5-benzyloxy-2-oxopentyl)piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / potassium hydroxide / ethanol; H₂O / 4 h / Ambient temperature

2: 81 percent / hydrogen / platinum oxide / ethanol / 760 Torr / Ambient temperature

3: 1) m-chloroperoxybenzoic acid; 2) trifluoroacetic anhydride; 3) NaOAc / 1) CH₂Cl₂, 0 deg C, 1 h; 2) CH₂Cl₂, a) -15 deg C, 1 h, b) room temp., 1h; 3) H₂O, CH₂Cl₂, room temp., 30 min

With potassium hydroxide; hydrogen; sodium acetate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; platinum(IV) oxide; In ethanol; water;
DOI:10.1016/S0040-4020(01)92254-9

Reference yield:

: 141764-65-0
Diethyl 5-Benzyloxy-2-oxopentylphosphonate

: 141764-68-3
trans-1-Benzyl-4-(5-benzyloxy-2-oxopentyl)piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / potassium hydroxide / ethanol; H₂O / 4 h / Ambient temperature

2: 81 percent / hydrogen / platinum oxide / ethanol / 760 Torr / Ambient temperature

3: 1) m-chloroperoxybenzoic acid; 2) trifluoroacetic anhydride; 3) NaOAc / 1) CH₂Cl₂, 0 deg C, 1 h; 2) CH₂Cl₂, a) -15 deg C, 1 h, b) room temp., 1h; 3) H₂O, CH₂Cl₂, room temp., 30 min

With potassium hydroxide; hydrogen; sodium acetate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; platinum(IV) oxide; In ethanol; water;
DOI:10.1016/S0040-4020(01)92254-9