5-Pyrimidinecarboxylic acid, 2-methyl-4-[propyl[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino] -, ethyl ester

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 2-methyl-4-[propyl[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino] -, ethyl ester
CAS No.:141871-76-3
Molecular Formula:C25H27N7O2
Molecular Weight:457.535
Hs Code.:
Mol file:141871-76-3.mol

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Chemical Property of 5-Pyrimidinecarboxylic acid, 2-methyl-4-[propyl[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino] -, ethyl ester

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Technology Process of 5-Pyrimidinecarboxylic acid, 2-methyl-4-[propyl[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino] -, ethyl ester

There total 3 articles about 5-Pyrimidinecarboxylic acid, 2-methyl-4-[propyl[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino] -, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 143618-25-1
2-Methyl-4-{propyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyrimidine-5-carboxylic acid ethyl ester

: 141871-76-3
2-Methyl-4-{propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; In ethanol; for 2h; Ambient temperature;
DOI:10.1021/jm00098a018

Reference yield: 57.0%

: 141871-76-3
ethyl 2-methyl-4-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

Guidance literature:

Reference yield:

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 141871-76-3
2-Methyl-4-{propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 2 h

3: 88percent aq. HCOOH / CH₂Cl₂ / 2 h / Ambient temperature

With formic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00070a012