5-Pyrimidinecarboxamide, 4-[[2-[[2-(acetyloxy)ethyl]amino]ethyl]amino]-1,2-dihydro-6-methyl-N-(4- methylphenyl)-2-oxo-

Base Information

• Chemical Name: 5-Pyrimidinecarboxamide, 4-[[2-[[2-(acetyloxy)ethyl]amino]ethyl]amino]-1,2-dihydro-6-methyl-N-(4- methylphenyl)-2-oxo-
• CAS No.: 141883-34-3
• Molecular Formula: C₁₉H₂₅N₅O₄
• Molecular Weight: 387.439
• Mol file: 141883-34-3.mol

Synonyms:

Chemical Property of 5-Pyrimidinecarboxamide, 4-[[2-[[2-(acetyloxy)ethyl]amino]ethyl]amino]-1,2-dihydro-6-methyl-N-(4- methylphenyl)-2-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Pyrimidinecarboxamide, 4-[[2-[[2-(acetyloxy)ethyl]amino]ethyl]amino]-1,2-dihydro-6-methyl-N-(4- methylphenyl)-2-oxo-

There total 4 articles about 5-Pyrimidinecarboxamide, 4-[[2-[[2-(acetyloxy)ethyl]amino]ethyl]amino]-1,2-dihydro-6-methyl-N-(4- methylphenyl)-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

acetic anhydride (108-24-7) + 5-p-chlorofenylokarbamoilo-4-N-(N'-2'-hydroksyetylo)etylenodiamino-6-metylo-2-okso-1,2-dihydropirymidyna (141883-27-4) → Acetic acid 2-[2-(6-methyl-2-oxo-5-p-tolylcarbamoyl-2,3-dihydro-pyrimidin-4-ylamino)-ethylamino]-ethyl ester (141883-34-3)

Guidance literature:

for 1h; Heating;

Reference yield: 65.0%

acetic anhydride (108-24-7) + 6-[2-(2-Hydroxy-ethylamino)-ethylamino]-4-methyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid p-tolylamide (141883-28-5) → Acetic acid 2-[2-(6-methyl-2-oxo-5-p-tolylcarbamoyl-2,3-dihydro-pyrimidin-4-ylamino)-ethylamino]-ethyl ester (141883-34-3)

Guidance literature:

for 1h; Heating;

Reference yield:

5-p-Chlorophenylcarbamoyl-2-oxo-4-thioxo-6-methyl-1,2,3,4-tetrahydropyrimidine (51622-69-6) → Acetic acid 2-[2-(6-methyl-2-oxo-5-p-tolylcarbamoyl-2,3-dihydro-pyrimidin-4-ylamino)-ethylamino]-ethyl ester (141883-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / pyridine / 6 h / Heating

2: 65 percent / 1 h / Heating

With pyridine;

upstream raw materials:

acetic anhydride

6-[2-(2-Hydroxy-ethylamino)-ethylamino]-4-methyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid p-tolylamide

5-p-chlorofenylokarbamoilo-4-N-(N'-2'-hydroksyetylo)etylenodiamino-6-metylo-2-okso-1,2-dihydropirymidyna

1,2,3,4-Tetrahydro-6-methyl-2-oxo-4-thio-5-p-tolylcarbamoylpyrimidine