L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-D-2-phenylglycyl-N-[1-formyl-4-[imino[[[ (phenylmethoxy)carbonyl]amino]methyl]amino]butyl]-, (S)-

Base Information

Chemical Name:L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-D-2-phenylglycyl-N-[1-formyl-4-[imino[[[ (phenylmethoxy)carbonyl]amino]methyl]amino]butyl]-, (S)-
CAS No.:141973-01-5
Molecular Formula:C32H42N6O7
Molecular Weight:622.721
Hs Code.:

L-Prolinamide,
N-[(1,1-dimethylethoxy)carbonyl]-D-2-phenylglycyl-N-[1-formyl-4-[imino[[[
(phenylmethoxy)carbonyl]amino]methyl]amino]butyl]-, (S)-

Synonyms:

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Chemical Property of L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-D-2-phenylglycyl-N-[1-formyl-4-[imino[[[ (phenylmethoxy)carbonyl]amino]methyl]amino]butyl]-, (S)-

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Technology Process of L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-D-2-phenylglycyl-N-[1-formyl-4-[imino[[[ (phenylmethoxy)carbonyl]amino]methyl]amino]butyl]-, (S)-

There total 4 articles about L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-D-2-phenylglycyl-N-[1-formyl-4-[imino[[[ (phenylmethoxy)carbonyl]amino]methyl]amino]butyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 141973-01-5
C₃₂H₄₂N₆O₇

Guidance literature:: Multi-step reaction with 4 steps

1: DCC / ethyl acetate / 2.5 h / 0 - 20 °C

2: pyridine, triethylemine / 24 h / Ambient temperature

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, -15 deg C, 2 min, 2.) DMF, a.) -15 deg C, 4 h, b.) RT, 24 h

4: LiAlH₄ / tetrahydrofuran / 0.5 h / -60 °C

With 4-methyl-morpholine; pyridine; lithium aluminium tetrahydride; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00055a002

Reference yield:

: 141973-00-4
((R)-2-{(S)-2-[(S)-1-(Benzyloxycarbonylamino-imino-methyl)-2-oxo-piperidin-3-ylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-1-phenyl-ethyl)-carbamic acid tert-butyl ester

: 141973-01-5
C₃₂H₄₂N₆O₇

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -60 ℃; for 0.5h;
DOI:10.1021/jm00055a002

Reference yield:

: (R)-1-((R)-2-tert-Butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid

: 141973-01-5
C₃₂H₄₂N₆O₇

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, -15 deg C, 2 min, 2.) DMF, a.) -15 deg C, 4 h, b.) RT, 24 h

2: LiAlH₄ / tetrahydrofuran / 0.5 h / -60 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1021/jm00055a002