NOR-DESOXYCHOLIC ACID

Base Information

• Chemical Name: NOR-DESOXYCHOLIC ACID
• CAS No.: 53608-86-9
• Molecular Formula: C₂₃H₃₈O₄
• Molecular Weight: 378.552
• Mol file: 53608-86-9.mol

Synonyms:(3R)-3-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]butanoic acid;

Chemical Property of NOR-DESOXYCHOLIC ACID

Chemical Property:

• Vapor Pressure: 9.33E-14mmHg at 25°C
• Melting Point: 213.5-214.5oC
• Boiling Point: 536.7°Cat760mmHg
• PKA: 4.71±0.10(Predicted)
• Flash Point: 292.4°C
• PSA: 77.76000
• Density: 1.142g/cm³
• LogP: 4.08780
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone, Dichloromethane, DMSO (Slightly), Ethanol (Sparingly, Heated, Sonicated

Purity/Quality:

98%Min ^*data from raw suppliers

Nor-DeoxycholicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A derivative of Deoxycholic acid (DC); the bile acid bolized to mostly ester glucuronides and hydroxylated derivatives. A derivative of Deoxycholic Acid (DC); the bile acid nor-DC showed considerable and continuing efflux into the perfusate; this involved mostly the unchanged acid. Nor-DC was not amidated but was metabolized to mostly ester glucuronides and hydroxylated derivatives.

Technology Process of NOR-DESOXYCHOLIC ACID

There total 5 articles about NOR-DESOXYCHOLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3α.12α-Diacetoxy-24-nor-5β-cholansaeure-(23) (63714-58-9) → 23-Nordeoxycholic acid (53608-86-9)

Guidance literature:

With potassium hydroxide;

Reference yield:

→ 3α,12α-dihydroxy-24-nor-5β.20βFH-cholanoic acid-(23) (53608-86-9,111239-26-0)

Guidance literature:

With potassium hydroxide;

DOI:10.1002/hlca.194402701196

Reference yield:

24.24-dimethyl-5β-cholanetriol-(3α.12α.24) (82069-00-9) → 23-Nordeoxycholic acid (53608-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Erwaermen des Reaktionsprodukts mit CrO₃ in Essigsaeure

2: aq.-ethanolic KOH-solution

With pyridine; potassium hydroxide;

upstream raw materials:

3α.12α-Diacetoxy-24-nor-5β-cholansaeure-(23)

24.24-dimethyl-5β-cholanetriol-(3α.12α.24)

methyl deoxycholate

Downstream raw materials:

sodium 3α,12α-dihydroxy-24-nor-5β-cholane-23-sulfonate

23-p-toluenesulfoxy-24-nor-5β-cholane-3α,12α-diol