N-3'-(2-hydroxypropyl)histidine

Base Information

• Chemical Name: N-3'-(2-hydroxypropyl)histidine
• CAS No.: 81790-79-6
• Molecular Formula: C₉H₁₅N₃O₃
• Molecular Weight: 213.236
• Mol file: 81790-79-6.mol

Synonyms:N-3’-(2-hydroxypropyl)histidine

Chemical Property of N-3'-(2-hydroxypropyl)histidine

Chemical Property:

• Vapor Pressure: 3.27E-10mmHg at 25°C
• Boiling Point: 484.8°C at 760 mmHg
• Flash Point: 247°C
• PSA: 101.37000
• Density: 1.4g/cm³
• LogP: -0.08140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-3'-(2-hydroxypropyl)histidine

There total 4 articles about N-3'-(2-hydroxypropyl)histidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N(α)-benzyloxycarbonyl-N(τ)-(2-oxopropyl)-L-histidine methyl ester (87867-04-7) → N(τ)-(2-hydroxypropyl)-L-histidine (81790-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaBH₄ / methanol / 0.25 h

2: cyclohexa-1,4-diene / palladium-on-charcoal / acetic acid / 1 h

3: 6M HCl / 4 h / Heating

With hydrogenchloride; sodium tetrahydroborate; cyclohexa-1,4-diene; palladium on activated charcoal; In methanol; acetic acid;

Reference yield:

N(α)-benzyloxycarbonyl-N(τ)-(2-hydroxypropyl)-L-histidine methyl ester (87867-05-8) → N(τ)-(2-hydroxypropyl)-L-histidine (81790-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: cyclohexa-1,4-diene / palladium-on-charcoal / acetic acid / 1 h

2: 6M HCl / 4 h / Heating

With hydrogenchloride; cyclohexa-1,4-diene; palladium on activated charcoal; In acetic acid;

Reference yield:

N(α)-benzyloxycarbonyl-L-histidine methyl ester silver salt (68262-66-8) → N(τ)-(2-hydroxypropyl)-L-histidine (81790-79-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 44 percent / dimethylsulfoxide; CHCl₃ / 1 h

2: 85 percent / NaBH₄ / methanol / 0.25 h

3: cyclohexa-1,4-diene / palladium-on-charcoal / acetic acid / 1 h

4: 6M HCl / 4 h / Heating

With hydrogenchloride; sodium tetrahydroborate; cyclohexa-1,4-diene; palladium on activated charcoal; In methanol; chloroform; acetic acid; dimethyl sulfoxide;

upstream raw materials:

N(α)-benzyloxycarbonyl-N(τ)-(2-oxopropyl)-L-histidine methyl ester

N(α)-benzyloxycarbonyl-N(τ)-(2-hydroxypropyl)-L-histidine methyl ester

N(α)-benzyloxycarbonyl-L-histidine methyl ester silver salt

Refernces