4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile

Base Information

Chemical Name:4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile
CAS No.:142161-55-5
Molecular Formula:C14H10N4
Molecular Weight:234.26
Hs Code.:
DSSTox Substance ID:DTXSID201211236

Synonyms:SCHEMBL9726854;4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile;DTXSID201211236;142161-55-5

Suppliers and Price of 4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:234.090546336
Heavy Atom Count:18
Complexity:339

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC2=C(N1C3=CC=C(C=C3)C#N)N=CC=C2

Technology Process of 4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile

There total 5 articles about 4-(2-Methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 108-24-7
acetic anhydride

: 122957-66-8
4-(3-aminopyridin-2-ylamino)benzonitrile

: 142161-55-5
3-(4-cyanophenyl)-2-methylimidazol<4,5-b>pyridine

Guidance literature:: In acetic acid; for 5h; Heating;
DOI:10.1021/jm00095a005

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 142161-55-5
3-(4-cyanophenyl)-2-methylimidazol<4,5-b>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / ethanol / 72 h / Heating

2: 95 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 2.5 h / 20 °C / 1551.4 Torr

3: 77 percent / acetic acid / 5 h / Heating

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00095a005

Reference yield:

: 122957-65-7
4-(3-nitropyridin-2-ylamino)benzonitrile

: 142161-55-5
3-(4-cyanophenyl)-2-methylimidazol<4,5-b>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 2.5 h / 20 °C / 1551.4 Torr

2: 77 percent / acetic acid / 5 h / Heating

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00095a005