1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-oxide

Base Information

• Chemical Name: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-oxide
• CAS No.: 95969-40-7
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol file: 95969-40-7.mol

Synonyms:

Chemical Property of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-oxide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-oxide

There total 5 articles about 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (23007-85-4) → 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide (95969-40-7)

Guidance literature:

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride; With sodium ethanolate; In ethanol; at 0 ℃;

With dihydrogen peroxide; In ethanol; water; at 50 ℃;

DOI:10.1089/ars.2015.6297

Reference yield: 94.0%

1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (28289-54-5) → 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide (95969-40-7)

Guidance literature:

With dihydrogen peroxide; In ethanol; at 50 ℃; for 8h;

DOI:10.1002/hlca.19840670803

Reference yield:

phenyllithium (591-51-5) → 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide (95969-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dibutyl ether; tetrahydrofuran / -78 - 20 °C

2.1: hydrogenchloride / water / 5 h / Reflux

3.1: sodium ethanolate / ethanol / 0 °C

3.2: 50 °C

With hydrogenchloride; sodium ethanolate; In tetrahydrofuran; ethanol; dibutyl ether; water;

DOI:10.1089/ars.2015.6297

upstream raw materials:

1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1-Methyl-4-piperidone

phenyllithium

1-methyl-4-phenyl-piperidin-4-ol

Downstream raw materials:

1,2,5,6-tetrahydro-1-methyl-4-phenyl-2-pyridine carbonitrile

4-phenyl-N-methylpyridinium iodide