Carbamic acid, [4-(2-hydroxyethyl)-2-oxo-1-(phenylmethoxy)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, cis-

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Chemical Name:Carbamic acid, [4-(2-hydroxyethyl)-2-oxo-1-(phenylmethoxy)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, cis-
CAS No.:142229-21-8
Molecular Formula:C18H26N2O5
Molecular Weight:350.415
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [4-(2-hydroxyethyl)-2-oxo-1-(phenylmethoxy)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, cis-

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Technology Process of Carbamic acid, [4-(2-hydroxyethyl)-2-oxo-1-(phenylmethoxy)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, cis-

There total 7 articles about Carbamic acid, [4-(2-hydroxyethyl)-2-oxo-1-(phenylmethoxy)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142229-32-1,142229-33-2
iso-propyl 5-tert.-butyldiphenylsilyloxy-2-hydroxy-3-hydroxyliminomethylpentanoate

: 142229-21-8
cis 1-benzyloxy-3-tert.-butyloxycarbonylamino-4-(2-hydroxyethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine-borane complex, 10percent aqueous hydrochloric acid / ethanol / Ambient temperature

2: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.

3: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C

4: methanol

5: 90 percent / hydrogen, acetic acid / platinum(IV) oxide / ethyl acetate / 760 Torr

6: 67 percent / dichlorodicyanobenzoquinone, water / CH₂Cl₂ / a) 1 h, b) repeated proceeding, 1 h

7: 1) 4-dimethylaminopyridine, 2) tetrabutylammonium fluoride / 1) CH₂Cl₂, overnight, 2) THF, 1 h

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; water; hydrogen; sodium methylate; borane pyridine complex; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; platinum(IV) oxide; In methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)88493-3

Reference yield:

: 5-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-3-hydroxyaminomethyl-pentanoic acid isopropyl ester

: 142229-21-8
cis 1-benzyloxy-3-tert.-butyloxycarbonylamino-4-(2-hydroxyethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.

2: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C

3: methanol

4: 90 percent / hydrogen, acetic acid / platinum(IV) oxide / ethyl acetate / 760 Torr

5: 67 percent / dichlorodicyanobenzoquinone, water / CH₂Cl₂ / a) 1 h, b) repeated proceeding, 1 h

6: 1) 4-dimethylaminopyridine, 2) tetrabutylammonium fluoride / 1) CH₂Cl₂, overnight, 2) THF, 1 h

With dmap; tetrabutyl ammonium fluoride; water; hydrogen; sodium methylate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; platinum(IV) oxide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)88493-3

Reference yield:

: 142229-34-3,142229-35-4
1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-hydroxy-2-pyrrolidinone

: 142229-21-8
cis 1-benzyloxy-3-tert.-butyloxycarbonylamino-4-(2-hydroxyethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C

2: methanol

3: 90 percent / hydrogen, acetic acid / platinum(IV) oxide / ethyl acetate / 760 Torr

4: 67 percent / dichlorodicyanobenzoquinone, water / CH₂Cl₂ / a) 1 h, b) repeated proceeding, 1 h

5: 1) 4-dimethylaminopyridine, 2) tetrabutylammonium fluoride / 1) CH₂Cl₂, overnight, 2) THF, 1 h

With dmap; tetrabutyl ammonium fluoride; water; hydrogen; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; platinum(IV) oxide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)88493-3