2-[(3-methyl-4-nitro-2-pyridyl)methylsulfinyl]-1H-benzimidazole

Base Information

• Chemical Name: 2-[(3-methyl-4-nitro-2-pyridyl)methylsulfinyl]-1H-benzimidazole
• CAS No.: 142384-07-4
• Molecular Formula: C14H12N4O3S
• Mol file: 142384-07-4.mol

Synonyms:

Chemical Property of 2-[(3-methyl-4-nitro-2-pyridyl)methylsulfinyl]-1H-benzimidazole

Chemical Property:

• Vapor Pressure: 7.62E-16mmHg at 25°C

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(3-methyl-4-nitro-2-pyridyl)methylsulfinyl]-1H-benzimidazole

There total 4 articles about 2-[(3-methyl-4-nitro-2-pyridyl)methylsulfinyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole (152402-98-7) → (S)-(-)-2-(3-methyl-4-nitropyridin-2-ylmethansulfinyl)-1H-benzimidazole (142384-07-4)

Guidance literature:

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole; diethyl (2R,3R)-tartrate; In tetrahydrofuran; for 0.5h; Reflux;

titanium(IV) isopropylate; In tetrahydrofuran; Reflux;

With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -5 - 0 ℃;

Reference yield: 58.3%

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole (152402-98-7) → (R)-(+)-2-(3-methyl-4-nitropyridin-2-ylmethansulfinyl)-1H-benzimidazole (853950-77-3,142384-07-4)

Guidance literature:

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole; With titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; water; In toluene; at 65 - 70 ℃; Inert atmosphere; Large scale reaction;

With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine; In toluene; at 0 - 5 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Large scale reaction;

DOI:10.1016/j.tetlet.2011.08.033

Reference yield:

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole (152402-98-7) → (R)-(+)-2-(3-methyl-4-nitropyridin-2-ylmethansulfinyl)-1H-benzimidazole (853950-77-3,142384-07-4) + (S)-(-)-2-(3-methyl-4-nitropyridin-2-ylmethansulfinyl)-1H-benzimidazole (142384-07-4)

Guidance literature:

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole; With titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; water; In toluene; at 65 - 70 ℃; Inert atmosphere;

With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine; In toluene; at 0 - 5 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.08.033

upstream raw materials:

2-[(4-nitro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole

Downstream raw materials:

(S)-lansoprazole

lansoprasole

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF DEXLANSOPRAZOLE". Page/Page column 3. . Retrieved 2010/06/13.