Thymidine, 3'-deoxy-3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphen yl)-1-oxopropyl]amino]-, (S)-

Base Information

• Chemical Name: Thymidine, 3'-deoxy-3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphen yl)-1-oxopropyl]amino]-, (S)-
• CAS No.: 142410-19-3
• Molecular Formula: C25H34N4O8
• Molecular Weight: 518.567
• Mol file: 142410-19-3.mol

Synonyms:

Chemical Property of Thymidine, 3'-deoxy-3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphen yl)-1-oxopropyl]amino]-, (S)-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thymidine, 3'-deoxy-3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphen yl)-1-oxopropyl]amino]-, (S)-

There total 1 articles about Thymidine, 3'-deoxy-3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-methoxyphen yl)-1-oxopropyl]amino]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

O-methyl-N-tert-butoxycarbonyl-L-tyrosine (53267-93-9) + 3'-amino-3'-deoxythymidine (52450-18-7) → 1-(2,3-dideoxy-3-(N-t-butyloxycarbonyl-p-methoxy-L-phenylalanylamino)-β-D-erythro-pentofuranosyl)thymine (142410-19-3)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1002/jhet.5570290102

Reference yield: 56.0%

1-(2,3-dideoxy-3-(N-t-butyloxycarbonyl-p-methoxy-L-phenylalanylamino)-β-D-erythro-pentofuranosyl)thymine (142410-19-3) → 1-(2,3-dideoxy-3-p-methoxy-L-phenylalanylamino-β-D-erythro-pentofuranosyl)thymine (923056-89-7)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 0.0833333h;

DOI:10.1002/jhet.5570290102

upstream raw materials:

O-methyl-N-tert-butoxycarbonyl-L-tyrosine

3'-amino-3'-deoxythymidine

Downstream raw materials:

1-(2,3-dideoxy-3-p-methoxy-L-phenylalanylamino-β-D-erythro-pentofuranosyl)thymine

Refernces