2-Thiophenepentanoic acid, 4-(3-phenylpropyl)-

Base Information

• Chemical Name: 2-Thiophenepentanoic acid, 4-(3-phenylpropyl)-
• CAS No.: 142422-57-9
• Molecular Formula: C18H22O2S
• Molecular Weight: 302.437
• Mol file: 142422-57-9.mol

Synonyms:

Chemical Property of 2-Thiophenepentanoic acid, 4-(3-phenylpropyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiophenepentanoic acid, 4-(3-phenylpropyl)-

There total 3 articles about 2-Thiophenepentanoic acid, 4-(3-phenylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Oxo-5-[4-(3-phenyl-propyl)-thiophen-2-yl]-pentanoic acid methyl ester (142422-99-9) → 5-<4-(3-phenylpropyl)-2-thienyl>pentanoic acid (142422-57-9)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In various solvent(s); at 210 ℃; for 4h; Yield given;

DOI:10.1021/jm00095a011

Reference yield:

1-phenyl-3-(thiophen-3-yl)propan-1-one (71778-01-3) → 5-<4-(3-phenylpropyl)-2-thienyl>pentanoic acid (142422-57-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

2: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

3: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

With potassium hydroxide; tin(IV) chloride; hydrazine hydrate; In 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

Reference yield:

3-(3-phenylpropyl)thiophene (120245-35-4) → 5-<4-(3-phenylpropyl)-2-thienyl>pentanoic acid (142422-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

With potassium hydroxide; tin(IV) chloride; hydrazine hydrate; In 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

upstream raw materials:

5-Oxo-5-[4-(3-phenyl-propyl)-thiophen-2-yl]-pentanoic acid methyl ester

1-phenyl-3-(thiophen-3-yl)propan-1-one

3-(3-phenylpropyl)thiophene

Refernces