Benzoic acid, 2-[3-oxo-6-(2-propynyloxy)-3H-xanthen-9-yl]-, 2-propynyl ester

Base Information

• Chemical Name: Benzoic acid, 2-[3-oxo-6-(2-propynyloxy)-3H-xanthen-9-yl]-, 2-propynyl ester
• CAS No.: 142457-78-1
• Molecular Formula: C26H16O5
• Molecular Weight: 408.41
• Mol file: 142457-78-1.mol

Synonyms:

Chemical Property of Benzoic acid, 2-[3-oxo-6-(2-propynyloxy)-3H-xanthen-9-yl]-, 2-propynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-[3-oxo-6-(2-propynyloxy)-3H-xanthen-9-yl]-, 2-propynyl ester

There total 3 articles about Benzoic acid, 2-[3-oxo-6-(2-propynyloxy)-3H-xanthen-9-yl]-, 2-propynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

propargyl bromide (106-96-7) + fluorescein free acid (518-45-6) → dipropargyl fluorescein (142457-78-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1055/s-2006-941564

Reference yield: 65.0%

propargyl bromide (106-96-7) + fluorescein (2321-07-5,126605-73-0) → dipropargyl fluorescein (142457-78-1)

Guidance literature:

fluorescein; With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;

propargyl bromide; In N,N-dimethyl-formamide; at 120 ℃; for 4h; Inert atmosphere;

DOI:10.1002/asia.201402029

Reference yield: 9.5%

propargyl bromide (106-96-7) + fluorescein (2321-07-5,126605-73-0) → dipropargyl fluorescein (142457-78-1) + 3',6'-Bis(2-propinyloxy)spiro (142457-79-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

upstream raw materials:

propargyl bromide

fluorescein

fluorescein free acid

Downstream raw materials:

2-(6-[(1-(5(S)benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-1H-1,2,3-triazol-4-yl)methoxy]-3-oxo-3H-xanthen-9-yl)-benzoic acid (1-(5(S)-benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-1H-1,2,3-triazol-4-yl)methyl ester

2-(6-[(1-(2(S)-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-1H-1,2,3-triazol-4-yl)methoxy]-3-oxo-3H-xanthen-9-yl)-benzoic acid (1-(2(S)-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-1,2,3-triazol-4-yl)methyl ester