4-amino-2,3-dihydroxy-N-[1-(8-hydroxy-1-oxo-3,4-dihydro-1H-isochromen-3-yl)-3-methylbutyl]-5-methylhexanamide (non-preferred name)

Base Information

• Chemical Name: 4-amino-2,3-dihydroxy-N-[1-(8-hydroxy-1-oxo-3,4-dihydro-1H-isochromen-3-yl)-3-methylbutyl]-5-methylhexanamide (non-preferred name)
• CAS No.: 126262-07-5
• Molecular Formula: C₂₁H₃₂N₂O₆
• Molecular Weight: 408.495
• Mol file: 126262-07-5.mol

Synonyms:(-)-Y05460M-A; Y 05460MA

Chemical Property of 4-amino-2,3-dihydroxy-N-[1-(8-hydroxy-1-oxo-3,4-dihydro-1H-isochromen-3-yl)-3-methylbutyl]-5-methylhexanamide (non-preferred name)

Chemical Property:

• Vapor Pressure: 9.57E-22mmHg at 25°C
• Boiling Point: 719.8°Cat760mmHg
• Flash Point: 389.1°C
• Density: 1.24g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-2,3-dihydroxy-N-[1-(8-hydroxy-1-oxo-3,4-dihydro-1H-isochromen-3-yl)-3-methylbutyl]-5-methylhexanamide (non-preferred name)

There total 5 articles about 4-amino-2,3-dihydroxy-N-[1-(8-hydroxy-1-oxo-3,4-dihydro-1H-isochromen-3-yl)-3-methylbutyl]-5-methylhexanamide (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C30H46N2O8 (1188511-27-4) → Y-05460M-A (126262-07-5)

Guidance literature:

C₃₀H₄₆N₂O₈; With boron tribromide; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1021/jo9014968

Reference yield: 55.0%

C15H27NO6 + (S)-3-[(S)-1-amino-3-methylbutyl]-8-methoxyisochroman-1-one (175236-18-7) → Y-05460M-A (126262-07-5)

Guidance literature:

C₁₅H₂₇NO₆; (S)-3-[(S)-1-amino-3-methylbutyl]-8-methoxyisochroman-1-one; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;

With boron tribromide; methoxybenzene; In dichloromethane; at -78 - -60 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02576

Reference yield:

N-methoxy-2-methoxybenzamide (701975-56-6) → Y-05460M-A (126262-07-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium acetate; palladium diacetate; copper dichloride / 24 h / 95 °C / Inert atmosphere; Sealed tube

2.1: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / 2 h / 20 °C

4.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

4.2: -78 - -60 °C / Inert atmosphere

With diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; potassium acetate; palladium diacetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; copper dichloride; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.1c02576

upstream raw materials:

C₃₀H₄₆N₂O₈

N-methoxy-2-methoxybenzamide

(3S)-3-<(1'R)-1'-hydroxy-3'-methylbutyl>-8-methoxy-3,4-dihydroisocoumarin

(3S)-3-<(1'S)-1'-azido-3'-methylbutyl>-8-methoxy-3,4-dihydroisocoumarin