Butanamide, 2-methyl-N-(phenylmethyl)-, (R)-

Base Information

• Chemical Name: Butanamide, 2-methyl-N-(phenylmethyl)-, (R)-
• CAS No.: 142797-98-6
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Mol file: 142797-98-6.mol

Synonyms:

Chemical Property of Butanamide, 2-methyl-N-(phenylmethyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanamide, 2-methyl-N-(phenylmethyl)-, (R)-

There total 3 articles about Butanamide, 2-methyl-N-(phenylmethyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzylamine (100-46-9) → (R)-(-)-N-benzyl-2-methylbutyramide (142797-98-6)

Guidance literature:

In toluene; for 1h; Ambient temperature;

DOI:10.1021/ja00043a006

Reference yield:

(S)-N-Benzyl-2-methyl-3-(toluene-4-sulfonyl)-butyramide → (R)-(-)-N-benzyl-2-methylbutyramide (142797-98-6) + (2S)-2-methyl-N-(phenylmethyl)-butanamide (142797-97-5)

Guidance literature:

With sodium amalgam; In methanol; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/S0040-4039(00)74098-6

Reference yield:

ethyl 2-methylbutyrate (7452-79-1,53956-13-1) + benzylamine (100-46-9) → (R)-(-)-N-benzyl-2-methylbutyramide (142797-98-6) + (2S)-2-methyl-N-(phenylmethyl)-butanamide (142797-97-5)

Guidance literature:

With Rhizomucor miehei lipase; hydrogenchloride; 2-amino-2-hydroxymethyl-1,3-propanediol; In water; ethyl acetate; at 25 ℃; for 72h; stereoselective lipase-catalyzed synthesis of chiral amides, other lipases;

DOI:10.1016/S0040-4020(98)83024-X

upstream raw materials:

ethyl 2-methylbutyrate

benzylamine

Refernces

• 1、 Satoh,Motohashi,Kimura,Tokutake,Yamakawa. "The asymmetric Favorskii rearrangement: A synthesis of optically active α-alkyl amides from aldehydes and (-)-1-chloroalkyl p-tolyl sulfoxide". . p. 4823 - 4826. Retrieved 2007/10/02.
• 2、 Joshi, Kiran,Bao, Jiang,Goldman, Alan S.,Kohn, Joachim. "Acylation reactions mediated by tantalum carboxylates". . p. 6649 - 6652. Retrieved 2007/10/02.