4-Bromo-5-chloroimidazole

Base Information

• Chemical Name: 4-Bromo-5-chloroimidazole
• CAS No.: 17487-98-8
• Molecular Formula: C₃H₂BrClN₂
• Molecular Weight: 181.419
• Mol file: 17487-98-8.mol

Synonyms:1H-Imidazole,4-bromo-5-chloro- (9CI);Imidazole, 4-bromo-5-chloro- (8CI);4-Bromo-5-chloroimidazole;NSC 222404;

Chemical Property of 4-Bromo-5-chloroimidazole

Chemical Property:

• Vapor Pressure: 2.91E-05mmHg at 25°C
• Refractive Index: 1.621
• Boiling Point: 367.3 °C at 760 mmHg
• Flash Point: 175.9 °C
• PSA: 28.68000
• Density: 2.035 g/cm³
• LogP: 1.82560

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-5-chloro-1H-imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-5-chloroimidazole

There total 2 articles about 4-Bromo-5-chloroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

4-bromo-1 H-imidazole (2302-25-2) → 4(5)-bromo-5(4)-chloroimidazole (17487-98-8)

Guidance literature:

4-bromo-1 H-imidazole; With sodium chlorine monoxide; sodium hydroxide; In water monomer; at 20 ℃; for 1.33333h;

With pyrographite; In water monomer; for 1h;

DOI:10.1016/j.poly.2022.115736

Reference yield:

→ 4(5)-bromo-5(4)-chloroimidazole (17487-98-8)

Guidance literature:

4-Bromimidazol, wss. NaOH, NaOCl (40grad);

Reference yield: 64.0%

trityl chloride (76-83-5) + 4(5)-bromo-5(4)-chloroimidazole (17487-98-8) → 4-bromo-5-chloro-1-tritylimidazole (112517-24-5)

Guidance literature:

With triethylamine; In benzene;

upstream raw materials:

4-bromo-1 H-imidazole

Downstream raw materials:

4-bromo-5-chloro-1-tritylimidazole

Refernces