4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-propylaniline trihydrochloride

Base Information

• Chemical Name: 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-propylaniline trihydrochloride
• CAS No.: 104655-25-6
• Molecular Formula: C23H33 N3 O2 . 3 Cl H
• Molecular Weight: 492.9098
• Mol file: 104655-25-6.mol

Synonyms:Benzenamine,4-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-N-propyl-, trihydrochloride(9CI)

Chemical Property of 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-propylaniline trihydrochloride

Chemical Property:

• Vapor Pressure: 1.37E-12mmHg at 25°C
• Boiling Point: 560.4°Cat760mmHg
• Flash Point: 292.7°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-propylaniline trihydrochloride

There total 2 articles about 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}-N-propylaniline trihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-<4-(Propionamido)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane (104655-14-3) → 1-<4-(N-Propylamino)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane hydrochloride (104655-25-6)

Guidance literature:

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; 1.) THF, reflux, 2.) ether;

Reference yield:

1-(4-aminophenoxy)-3-1-4-(2-methoxyphenyl)-piperazinyl>>propane (104655-08-5) → 1-<4-(N-Propylamino)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane hydrochloride (104655-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 0.5 h / 90 °C

2: 80 percent / 1.) LiAlH₄, 2.) HCl / tetrahydrofuran; diethyl ether / 1.) THF, reflux, 2.) ether

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

1-<4-(Propionamido)phenoxy>-3-1-4-(2-methoxyphenyl)piperazinyl>>propane

1-(4-aminophenoxy)-3-1-4-(2-methoxyphenyl)-piperazinyl>>propane