7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,6-dihydro-,rel-

Base Information

• Chemical Name: 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,6-dihydro-,rel-
• CAS No.: 125073-29-2
• Molecular Formula: C₁₀H₁₄N₆O₄
• Molecular Weight: 282.259
• Mol file: 125073-29-2.mol

Synonyms:7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,4-dihydro-, (1a,2a,3a,4a)- (9CI);7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,4-dihydro-, (1a,2a,3a,4a)-(?à)-

Chemical Property of 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,6-dihydro-,rel-

Chemical Property:

• Boiling Point: 502.9°Cat760mmHg
• Flash Point: 257.9°C
• Density: 2.28g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,6-dihydro-,rel-

There total 5 articles about 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3,6-dihydro-,rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.7%

(+/-)-(1α,2α,3α,5α)-3-(5-amino-7-chloro-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol (125073-28-1) → (+/-)-5-amino-3,6-dihydro-3-<(1α,2α,3α,4α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-7H-1,2,3-triazolo<4,5-d>pyrimidin-7-one (125073-29-2)

Guidance literature:

With hydrogenchloride; for 5h; Heating;

DOI:10.1021/jm00166a020

Reference yield:

(+/-)-(1α,2α,3α,5α)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol (87419-91-8,305384-32-1,780705-82-0) → (+/-)-5-amino-3,6-dihydro-3-<(1α,2α,3α,4α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-7H-1,2,3-triazolo<4,5-d>pyrimidin-7-one (125073-29-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 74.6 percent / Et₃N / butan-1-ol / 48 h / Heating

2: 1.) conc. HCl, NaNO₂, 2.) sodium acetate, glacial acetic acid / 1.) H₂O, 0 deg C, 0.5 h, 2.) RT, 42 h

3: 68.4 percent / Zn-glacial acetic acid / H₂O; ethanol / 2.5 h / Heating

4: 79.5 percent / NaNO₂, glacial acetic acid / H₂O / 2 h / 0 °C

5: 37.7 percent / 1 N HCl / 5 h / Heating

With hydrogenchloride; sodium acetate; acetic acid; triethylamine; zinc; sodium nitrite; In ethanol; water; butan-1-ol;

DOI:10.1021/jm00166a020

Reference yield:

(+/-)-(1α,2α,3α,5α)-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol (125073-22-5) → (+/-)-5-amino-3,6-dihydro-3-<(1α,2α,3α,4α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-7H-1,2,3-triazolo<4,5-d>pyrimidin-7-one (125073-29-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) conc. HCl, NaNO₂, 2.) sodium acetate, glacial acetic acid / 1.) H₂O, 0 deg C, 0.5 h, 2.) RT, 42 h

2: 68.4 percent / Zn-glacial acetic acid / H₂O; ethanol / 2.5 h / Heating

3: 79.5 percent / NaNO₂, glacial acetic acid / H₂O / 2 h / 0 °C

4: 37.7 percent / 1 N HCl / 5 h / Heating

With hydrogenchloride; sodium acetate; acetic acid; zinc; sodium nitrite; In ethanol; water;

DOI:10.1021/jm00166a020

upstream raw materials:

(+/-)-(1α,2α,3α,5α)-3-(5-amino-7-chloro-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol

(+/-)-(1α,2α,3α,5α)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol

(+/-)-(1α,2α,3α,5α)-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol

(+/-)-(1α,2α,3α,5α)-3-<(2,5-diamino-6-chloro-4-pyrimidinyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol