Carbamic acid, [4-(acetyloxy)-3-(chlorocarbonyl)phenyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [4-(acetyloxy)-3-(chlorocarbonyl)phenyl]-, phenylmethyl ester
• CAS No.: 143200-62-8
• Molecular Formula: C17H14ClNO5
• Molecular Weight: 347.755
• Mol file: 143200-62-8.mol

Synonyms:

Chemical Property of Carbamic acid, [4-(acetyloxy)-3-(chlorocarbonyl)phenyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [4-(acetyloxy)-3-(chlorocarbonyl)phenyl]-, phenylmethyl ester

There total 4 articles about Carbamic acid, [4-(acetyloxy)-3-(chlorocarbonyl)phenyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5--2-acetylsalicylic acid (143221-96-9) → 5--2-acetylsalicylic chloride (143200-62-8)

Guidance literature:

With pyridine; thionyl chloride; for 3h; Heating;

DOI:10.1021/jm00078a009

Reference yield:

5-Aminosalicylic Acid (89-57-6) → 5--2-acetylsalicylic chloride (143200-62-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / aq. NaHCO₃ / 5 h / 0 °C

2: 70 percent / pyridine / acetic acid / 2 h

3: 81 percent / SOCl₂, pyridine / 3 h / Heating

With pyridine; thionyl chloride; sodium hydrogencarbonate; In acetic acid;

DOI:10.1021/jm00078a009

Reference yield:

5-benzyloxycarbonylamino-2-hydroxy-benzoic acid (143200-61-7) → 5--2-acetylsalicylic chloride (143200-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridine / acetic acid / 2 h

2: 81 percent / SOCl₂, pyridine / 3 h / Heating

With pyridine; thionyl chloride; In acetic acid;

DOI:10.1021/jm00078a009

upstream raw materials:

5--2-acetylsalicylic acid

5-Aminosalicylic Acid

5-benzyloxycarbonylamino-2-hydroxy-benzoic acid

benzyl chloroformate

Downstream raw materials:

<(5-amino-2-acetylsalicyl)-L-prolyl>-L-leucine methyl ester

<<5--2-acetylsalicyl>-L-prolyl>-L-leucine methyl ester

Refernces